DegronMD

Uniprot ID: P47736

Source protein: Rap1 GTPase-activating protein 1

Source gene: RAP1GAP

Class: DEG_SPOP_SBC_1

Location: 617:621

E3 ligase: SPOP

DEGRON score: 0.9852

ASA_SCORE: 93.34

COIL: 0.9526

CONS_SCORE: 0.4116

DSS_SCORE: 0.5904

HELIX: 0.0272

FCONS_SCORE: 1.0229

RIG_SCORE: 0.6148

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A619T	TCGA-AA-3949	COAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.7139
p.A619T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.7139
p.R631S	TCGA-D3-A2JG	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	0.0556
p.A620G	TCGA-HC-A6AN	PRAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.754
p.V609M	DO228123	EOPC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.V609M	DO223007	ESCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.V609M	DO45368	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.E619G	DO25262	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.7199
p.V626M	DO51407	PRAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1944
p.G618R	DO47717	STAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.7568
p.G618R	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.7568
p.A607V	DO229216	THCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0556
p.G622C	DO223286	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.3056
p.G622D	DO43755	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.3056
p.V613I	SIDM00945	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.V613I	CL-34	large_intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.S629T	ACH-000004	Leukemia	CCLE	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S629T	ACH-000005	Leukemia	CCLE	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S629T	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S629P	ACH-000823	Esophageal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S629P	ACH-001394	Breast Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S629P	ACH-001688	Kidney Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.1111
p.A623V	NCI-H1155	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.G613R	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.T611M	NCI-H1092	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons