DegronMD

Uniprot ID: P13647

Source protein: Keratin, type II cytoskeletal 5

Source gene: KRT5

Class: DEG_SPOP_SBC_1

Location: 578:582

E3 ligase: SPOP

DEGRON score: 0.9568

ASA_SCORE: 88.44

COIL: 0.8916

CONS_SCORE: 0.3191

DSS_SCORE: 0.3826

HELIX: 0.02

FCONS_SCORE: 0.7965

RIG_SCORE: 0.7105

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G569W	TCGA-49-AARE	LUAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.0833
p.G569W	DO218922	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.G569W	DO41056	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.S582Y	TCGA-55-A490	LUAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.712
p.S582Y	DO24596	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.712
p.S587N	TCGA-A5-A0G2	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.6389
p.S587N	DO41235	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.6389
p.G569E	TCGA-FW-A3R5	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	0.0833
p.G569E	DO37406	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.V575I	DO233168	GACA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.25
p.S583F	SIDM00545	Melanoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.3056
p.S583F	ACH-000987	Skin Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.3056
p.S583F	Mewo	skin	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.3056
p.K586R	SIDM00845	Burkitt's Lymphoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.3333
p.S579Y	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.712
p.S579Y	EKVX	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.712
p.G569R	SIDM00529	Breast Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.V575F	ACH-001303	Neuroblastoma	CCLE	VSTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons