DegronMD - Q99963(SH3GL3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G280C	TCGA-AX-A06F	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667
p.P284L	TCGA-EE-A181	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0556
p.L267F	TCGA-EM-A1YB	THCA	TCGA	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.25
p.T278K	TCGA-N8-A4PM	UCS	TCGA	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.2222
p.G280D	TCGA-S5-A6DX	BLCA	TCGA	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667
p.T281S	DO50388	ESAD	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1389
p.R261L	DO228974	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation substituting flanking lysine	0.1944
p.R266M	DO229026	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.2222
p.K264N	DO49875	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation blocking phosphorylation signal	0.6111
p.R261Q	DO220877	MELA	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation substituting flanking lysine	0.1944
p.R261Q	DO37406	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation substituting flanking lysine	0.1944
p.R261Q	DO47631	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation substituting flanking lysine	0.1944
p.R261Q	DO219482	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation substituting flanking lysine	0.1944
p.E274K	DO222875	MELA	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.7022
p.L275F	DO39143	THCA	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.3056
p.P267H	DO41542	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.25
p.E262D	SIDM00656	Burkitt's Lymphoma	GDSC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1111
p.E262D	SIDM00844	Burkitt's Lymphoma	GDSC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1111
p.E262D	SIDM00785	Acute Myeloid Leukemia	GDSC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1111
p.E262D	SIDM00641	Burkitt's Lymphoma	GDSC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1111
p.E262D	SIDM01749	Osteosarcoma	GDSC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1111
p.S273R	SIDM00660	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.7427
p.S273R	LS-411N	large intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation altering degron motif	0.7427
p.S265R	ACH-000985	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation blocking phosphorylation signal	0.6389
p.S265R	LS-411N	large intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation blocking phosphorylation signal	0.6389
p.P284S	ACH-002309	Sarcoma	CCLE	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0556
p.P284S	SW684	soft tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.0556
p.G280S	NCI-H322M	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	270:274	Mutation rewiring degron network	0.1667

Kaplan plot for SH3GL3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3GL3

UniProt ID: Q99963

Entrez ID: 6457

Protein name: Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SH3GL3 in