DegronMD

Uniprot ID: Q99963

Source protein: Endophilin-A3

Source gene: SH3GL3

Class: DEG_SPOP_SBC_1

Location: 270:274

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 71.92

COIL: 0.8354

CONS_SCORE: 0.3651

DSS_SCORE: 0.5299

HELIX: 0.0544

FCONS_SCORE: 1.0545

RIG_SCORE: 0.6899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G280C	TCGA-AX-A06F	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.1667
p.P284L	TCGA-EE-A181	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	0.0556
p.L267F	TCGA-EM-A1YB	THCA	TCGA	VSTTS	DEG_SPOP_SBC_1	0.25
p.T278K	TCGA-N8-A4PM	UCS	TCGA	VSTTS	DEG_SPOP_SBC_1	0.2222
p.G280D	TCGA-S5-A6DX	BLCA	TCGA	VSTTS	DEG_SPOP_SBC_1	0.1667
p.T281S	DO50388	ESAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1389
p.R261L	DO228974	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1944
p.R266M	DO229026	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.K264N	DO49875	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.6111
p.R261Q	DO220877	MELA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1944
p.R261Q	DO37406	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1944
p.R261Q	DO47631	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1944
p.R261Q	DO219482	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1944
p.E274K	DO222875	MELA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.7022
p.L275F	DO39143	THCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.3056
p.P267H	DO41542	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.25
p.E262D	SIDM00656	Burkitt's Lymphoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.E262D	SIDM00844	Burkitt's Lymphoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.E262D	SIDM00785	Acute Myeloid Leukemia	GDSC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.E262D	SIDM00641	Burkitt's Lymphoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.E262D	SIDM01749	Osteosarcoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S273R	SIDM00660	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.7427
p.S273R	LS-411N	large_intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.7427
p.S265R	ACH-000985	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.6389
p.S265R	LS-411N	large_intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.6389
p.P284S	ACH-002309	Sarcoma	CCLE	VSTTS	DEG_SPOP_SBC_1	0.0556
p.P284S	SW684	soft_tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.0556
p.G280S	NCI-H322M	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTS

Degron related mutations and impact score

Drug responses associated with SH3GL3 mutations

All proteins holding degron of VSTTS