DegronMD - O95644(NFATC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S819T	TCGA-55-8299	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0556
p.A516D	TCGA-DD-AADG	LIHC	TCGA	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0556
p.S820G	TCGA-DM-A1HB	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.E495K	TCGA-EE-A29E	SKCM	TCGA	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1389
p.R515Q	TCGA-EY-A1GI	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation substituting flanking lysine	0.1944
p.S828L	TCGA-GN-A266	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.3056
p.S828L	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.3056
p.S506N	DO225346	BRCA	ICGC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.7069
p.P835H	DO223507	CLLE	ICGC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2778
p.Q493H	DO228974	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.L842P	DO228972	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.0833
p.V502L	DO229015	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.6765
p.V494L	DO229009	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1111
p.S832T	DO25927	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation altering degron motif	0.6005
p.S512F	DO222662	MELA	ICGC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation blocking phosphorylation signal	0.6111
p.S512F	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation blocking phosphorylation signal	0.6111
p.S512F	ACH-000012	Lung Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation blocking phosphorylation signal	0.6111
p.S512F	ACH-000029	Lung Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation blocking phosphorylation signal	0.6111
p.S512F	HCC-827	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation blocking phosphorylation signal	0.6111
p.G499W	DO37896	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.25
p.E508K	DO37831	SKCM	ICGC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.2778
p.S841L	DO37432	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.1111
p.S841L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.1111
p.S841L	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.1111
p.S831I	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation altering degron motif	0.7341
p.S831I	NCI-H2172	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation altering degron motif	0.7341
p.Q824R	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.1944
p.T498I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.2222
p.T498I	ACH-002256	Leukemia	CCLE	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.2222
p.T498I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.2222
p.A841T	ACH-000911	Gastric Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.1111
p.S499F	HCC-827	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.25

Kaplan plot for NFATC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFATC1

UniProt ID: O95644

Entrez ID: 4772

Protein name: Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFATC1 in