DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPSSS
Uniprot ID:
O95644
Source protein:
Nuclear factor of activated T-cells, cytoplasmic 1
Source gene:
NFATC1
Class:
DEG_SPOP_SBC_1
Location:
829:833
E3 ligase:
SPOP
DEGRON score:
0.9905
ASA_SCORE:
83.78
COIL:
0.9664
CONS_SCORE:
0.2954
DSS_SCORE:
0.6364
HELIX:
0.0152
FCONS_SCORE:
0.9209
RIG_SCORE:
0.4903
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S831I
SIDM00926
Non-Small Cell Lung Carcinoma
GDSC
PPSSS
DEG_SPOP_SBC_1
0.7341
p.S831I
NCI-H2172
lung
COSMIC
PPSSS
DEG_SPOP_SBC_1
0.7341
p.S832T
DO25927
LUAD
ICGC
PPSSS
DEG_SPOP_SBC_1
0.6005
p.S828L
TCGA-GN-A266
SKCM
TCGA
PPSSS
DEG_SPOP_SBC_1
0.3056
p.S828L
CML-T1
haematopoietic_and_lymphoid_tissue
COSMIC
PPSSS
DEG_SPOP_SBC_1
0.3056
p.P835H
DO223507
CLLE
ICGC
PPSSS
DEG_SPOP_SBC_1
0.2778
p.Q824R
SIDM00661
B-Cell Non-Hodgkin's Lymphoma
GDSC
PPSSS
DEG_SPOP_SBC_1
0.1944
p.S841L
DO37432
SKCM
ICGC
PPSSS
DEG_SPOP_SBC_1
0.1111
p.S841L
SIDM00958
Chronic Myelogenous Leukemia
GDSC
PPSSS
DEG_SPOP_SBC_1
0.1111
p.S841L
CML-T1
haematopoietic_and_lymphoid_tissue
COSMIC
PPSSS
DEG_SPOP_SBC_1
0.1111
p.A841T
ACH-000911
Gastric Cancer
CCLE
PPSSS
DEG_SPOP_SBC_1
0.1111
p.S820G
TCGA-DM-A1HB
COAD
TCGA
PPSSS
DEG_SPOP_SBC_1
0.0833
p.L842P
DO228972
LICA
ICGC
PPSSS
DEG_SPOP_SBC_1
0.0833
p.S819T
TCGA-55-8299
LUAD
TCGA
PPSSS
DEG_SPOP_SBC_1
0.0556
Showing 1 to 14 of 14 entries
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Drug responses associated with NFATC1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PPSSS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7L2J0
7SK snRNA methylphosphate capping enzyme
DEG_SPOP_SBC_1
355:359
PPSSS
SPOP
0.9939
More...
O94851
[F-actin]-monooxygenase MICAL2
DEG_SPOP_SBC_1
1285:1289
PPSSS
SPOP
0.8542
More...
Q2M3C7
A-kinase anchor protein SPHKAP
DEG_SPOP_SBC_1
1509:1513
PPSSS
SPOP
0.9954
More...
Q8NC96
Adaptin ear-binding coat-associated protein 1
DEG_SPOP_SBC_1
199:203
PPSSS
SPOP
0.9883
More...
P51825
AF4/FMR2 family member 1
DEG_SPOP_SBC_1
444:448
PPSSS
SPOP
0.8502
More...
Q86TB3
Alpha-protein kinase 2
DEG_SPOP_SBC_1
1642:1646
PPSSS
SPOP
0.917
More...
O75179
Ankyrin repeat domain-containing protein 17
DEG_SPOP_SBC_1
82:86
PPSSS
SPOP
0.9981
More...
O14497
AT-rich interactive domain-containing protein 1A
DEG_SPOP_SBC_1
252:256
PPSSS
SPOP
0.9757
More...
O60885
Bromodomain-containing protein 4
DEG_SPOP_SBC_1
482:486
PPSSS
SPOP
0.8891
More...
O94983
Calmodulin-binding transcription activator 2
DEG_SPOP_SBC_1
827:831
PPSSS
SPOP
0.9934
More...
Q8IXM2
Chromatin complexes subunit BAP18
DEG_SPOP_SBC_1
117:121
PPSSS
SPOP
0.9693
More...
Q9HCK8
Chromodomain-helicase-DNA-binding protein 8
DEG_SPOP_SBC_1
165:169
PPSSS
SPOP
0.8162
More...
Q5T3F8
CSC1-like protein 2
DEG_SPOP_SBC_1
796:800
PPSSS
SPOP
0.9523
More...
O14976
Cyclin-G-associated kinase
DEG_SPOP_SBC_1
781:785
PPSSS
SPOP
0.9989
More...
P51813
Cytoplasmic tyrosine-protein kinase BMX
DEG_SPOP_SBC_1
206:210
PPSSS
SPOP
0.9857
More...
Q92630
Dual specificity tyrosine-phosphorylation-regulated kinase 2
DEG_SPOP_SBC_1
568:572
PPSSS
SPOP
0.987
More...
Q96EV8
Dysbindin
DEG_SPOP_SBC_1
295:299
PPSSS
SPOP
0.9933
More...
Q14118
Dystroglycan 1
DEG_SPOP_SBC_1
810:814
PPSSS
SPOP
0.9752
More...
O95714
E3 ubiquitin-protein ligase HERC2
DEG_SPOP_SBC_1
2632:2636
PPSSS
SPOP
0.9299
More...
P50402
Emerin
DEG_SPOP_SBC_1
50:54
PPSSS
SPOP
0.9872
More...
Q9Y2L6
FERM domain-containing protein 4B
DEG_SPOP_SBC_1
799:803
PPSSS
SPOP
0.6205
More...
P04150
Glucocorticoid receptor
DEG_SPOP_SBC_1
405:409
PPSSS
SPOP
0.8508
More...
Q7Z4V5
Hepatoma-derived growth factor-related protein 2
DEG_SPOP_SBC_1
297:301
PPSSS
SPOP
0.9284
More...
Q7Z4V5
Hepatoma-derived growth factor-related protein 2
DEG_SPOP_SBC_1
393:397
PPSSS
SPOP
0.9958
More...
Q8WYB5
Histone acetyltransferase KAT6B
DEG_SPOP_SBC_1
1759:1763
PPSSS
SPOP
0.964
More...
Showing 1 to 25 of 85 entries
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