DegronMD - O14497(ARID1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K389Q	TCGA-05-4427	LUAD	TCGA	LARTPQPS	DEG_SCF_FBW7_1	374:381	Mutation substituting flanking lysine	0.2222
p.K389Q	DO23666	LUAD	ICGC	LARTPQPS	DEG_SCF_FBW7_1	374:381	Mutation substituting flanking lysine	0.2222
p.P1563T	TCGA-66-2727	LUSC	TCGA	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation altering degron motif	0.7031
p.P1563T	DO26478	LUSC	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation altering degron motif	0.7031
p.G1083C	TCGA-97-7938	LUAD	TCGA	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation altering degron motif	0.6489
p.G1083C	DO24329	LUAD	ICGC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation altering degron motif	0.6489
p.M918I	TCGA-A5-A0G2	UCEC	TCGA	PPGY	ITCH	912:915	Mutation rewiring degron network	0.25
p.M918I	DO47004	RECA	ICGC	PPGY	ITCH	912:915	Mutation rewiring degron network	0.25
p.M918I	DO41235	UCEC	ICGC	PPGY	ITCH	912:915	Mutation rewiring degron network	0.25
p.G1549D	TCGA-AP-A0LM	UCEC	TCGA	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1389
p.G1549D	DO43306	UCEC	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1389
p.R1566S	TCGA-AP-A1E1	UCEC	TCGA	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.2778
p.R1566S	DO43226	UCEC	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.2778
p.S1320Y	TCGA-AX-A0J0	UCEC	TCGA	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation altering degron motif	0.712
p.S1320Y	DO41133	UCEC	ICGC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation altering degron motif	0.712
p.L1309I	TCGA-AX-A2HC	UCEC	TCGA	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.1667
p.L1309I	DO41572	UCEC	ICGC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.1667
p.S1090I	TCGA-B5-A11E	UCEC	TCGA	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.2222
p.S1090I	DO41644	UCEC	ICGC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.2222
p.P1144S	TCGA-B5-A11E	UCEC	TCGA	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation altering degron motif	0.6752
p.P1144S	DO41644	UCEC	ICGC	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation altering degron motif	0.6752
p.G1549V	TCGA-BR-4184	STAD	TCGA	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1389
p.G1549V	DO38328	STAD	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1389
p.M923I	TCGA-CU-A5W6	BLCA	TCGA	PPGY	ITCH	912:915	Mutation rewiring degron network	0.1111
p.M923I	DO44059	BLCA	ICGC	PPGY	ITCH	912:915	Mutation rewiring degron network	0.1111
p.G1317W	TCGA-D1-A17C	UCEC	TCGA	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation altering degron motif	0.7825
p.G1317W	DO42841	UCEC	ICGC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation altering degron motif	0.7825
p.P1165Q	TCGA-D3-A3C6	SKCM	TCGA	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation altering degron motif	0.7035
p.P1165Q	DO37507	SKCM	ICGC	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation altering degron motif	0.7035
p.P1321S	TCGA-DA-A1IC	SKCM	TCGA	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.3056
p.P1321S	TCGA-FS-A1ZK	SKCM	TCGA	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.3056
p.P1321S	DO220891	MELA	ICGC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.3056
p.P1321S	DO37474	SKCM	ICGC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.3056
p.P1321S	DO37430	SKCM	ICGC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.3056
p.P136T	TCGA-DD-AAEG	LIHC	TCGA	PPAY	ITCH	145:148	Mutation rewiring degron network	0.0833
p.P136T	DO52271	LIHC	ICGC	PPAY	ITCH	145:148	Mutation rewiring degron network	0.0833
p.R1074L	TCGA-EE-A2GH	SKCM	TCGA	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.1111
p.R1074L	DO37643	SKCM	ICGC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.1111
p.M1154T	TCGA-EY-A1GF	UCEC	TCGA	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation rewiring degron network	0.2222
p.M1154T	TCGA-EY-A1GF	UCEC	TCGA	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation rewiring degron network	0.1111
p.M1154T	TCGA-EY-A1GF	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.25
p.M1154T	DO41704	UCEC	ICGC	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation rewiring degron network	0.2222
p.M1154T	DO41704	UCEC	ICGC	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation rewiring degron network	0.1111
p.M1154T	DO41704	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.25
p.P383S	TCGA-GF-A6C9	SKCM	TCGA	LARTPQPS	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.2778
p.P383S	DO222572	MELA	ICGC	LARTPQPS	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.2778
p.P383S	DO51254	SKCM	ICGC	LARTPQPS	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.2778
p.R1551H	TCGA-KK-A59V	PRAD	TCGA	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1944
p.R1551H	TCGA-PG-A917	UCEC	TCGA	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1944
p.R1551H	DO51346	PRAD	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1944
p.R1551H	DO52424	UCEC	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1944
p.R1323L	TCGA-NC-A5HH	LUSC	TCGA	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.25
p.R1323L	DO219187	LUSC	ICGC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.25
p.A1089T	TCGA-TM-A84M	LGG	TCGA	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.25
p.A1089T	DO50238	LGG	ICGC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.25
p.P1305S	TCGA-VP-A87J	PRAD	TCGA	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.0556
p.P1305S	DO51391	PRAD	ICGC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.0556
p.S1312Y	TCGA-ZF-A9RF	BLCA	TCGA	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.25
p.S1312Y	DO219074	BLCA	ICGC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.25
p.R1074W	DO225388	BRCA	ICGC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.1111
p.M1154I	DO227987	COCA	ICGC	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation rewiring degron network	0.2222
p.M1154I	DO227987	COCA	ICGC	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation rewiring degron network	0.1111
p.M1154I	DO227987	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.25
p.R911W	DO228299	LICA	ICGC	PPGY	ITCH	912:915	Mutation rewiring degron network	0.3056
p.L1080I	DO228672	LICA	ICGC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.2778
p.A1077T	DO228903	LICA	ICGC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.1944
p.D385Y	DO229025	LICA	ICGC	LARTPQPS	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.2222
p.P1553S	DO229004	LICA	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.25
p.V1561L	DO23164	LINC	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation altering degron motif	0.6765
p.E1156G	DO23490	LINC	ICGC	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation rewiring degron network	0.1667
p.E1156G	DO23490	LINC	ICGC	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation rewiring degron network	0.1667
p.E1156G	DO23490	LINC	ICGC	PQSTS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.1944
p.P251S	DO52688	MALY	ICGC	PPSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.3056
p.P251S	DO52688	MALY	ICGC	ASSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.1111
p.P1562L	DO220851	MELA	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation altering degron motif	0.6471
p.G1139V	DO45819	NBL	ICGC	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation rewiring degron network	0.1944
p.G1139V	DO45819	NBL	ICGC	PQSTS	DEG_SPOP_SBC_1	1147:1151	Mutation rewiring degron network	0.1111
p.P136H	DO232017	ORCA	ICGC	PPAY	ITCH	145:148	Mutation rewiring degron network	0.0833
p.P1553L	DO228017	SKCA	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.25
p.P135S	DO218859	SKCA	ICGC	PPAY	ITCH	145:148	Mutation rewiring degron network	0.0556
p.E1560D	DO41758	UCEC	ICGC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation altering degron motif	0.6758
p.I1173N	SIDM02059	Colorectal Carcinoma	GDSC	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation rewiring degron network	0.1944
p.P1144T	SIDM00131	Glioma	GDSC	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation altering degron motif	0.7031
p.P1144T	ACH-000329	Brain Cancer	CCLE	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation altering degron motif	0.7031
p.P1144T	CCF-STTG1	central nervous system	COSMIC	PQTPQST	DEG_SCF_FBW7_1	1144:1150	Mutation altering degron motif	0.7031
p.P153A	SIDM00845	Burkitt's Lymphoma	GDSC	PPAY	ITCH	145:148	Mutation rewiring degron network	0.1944
p.P153S	SIDM00025	Head and Neck Carcinoma	GDSC	PPAY	ITCH	145:148	Mutation rewiring degron network	0.1944
p.G1178A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation rewiring degron network	0.0556
p.G1178A	ACH-000929	Lung Cancer	CCLE	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation rewiring degron network	0.0556
p.G1178A	NCI-H2110	lung	COSMIC	PPTPAST	DEG_SCF_FBW7_1	1162:1168	Mutation rewiring degron network	0.0556
p.A259P	SIDM00382	Glioblastoma	GDSC	ASSSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.6392
p.A259P	ACH-000609	Brain Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	259:263	Mutation altering degron motif	0.6392
p.P1326L	SIDM00837	Colorectal Carcinoma	GDSC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.1667
p.P1326L	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.1667
p.P1321L	SIDM00502	B-Lymphoblastic Leukemia	GDSC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.3056
p.S1322G	SIDM00794	Other Solid Cancers	GDSC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.2778
p.S1322G	ACH-001442	Skin Cancer	CCLE	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.2778
p.S1322G	A388	skin	COSMIC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.2778
p.S1151N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PQSTS	DEG_SPOP_SBC_1	1147:1151	Mutation altering degron motif	0.7069
p.S1151N	ACH-001737	Leukemia	CCLE	PQSTS	DEG_SPOP_SBC_1	1147:1151	Mutation altering degron motif	0.7069
p.S1151N	ACH-002222	Leukemia	CCLE	PQSTS	DEG_SPOP_SBC_1	1147:1151	Mutation altering degron motif	0.7069
p.S1151N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PQSTS	DEG_SPOP_SBC_1	1147:1151	Mutation altering degron motif	0.7069
p.A247V	SIDM00083	Glioblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1944
p.A247V	ACH-000273	Brain Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	252:256	Mutation rewiring degron network	0.1944
p.P1307S	SIDM01608	Endometrial Carcinoma	GDSC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.1111
p.P1307S	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.1111
p.G272V	ACH-000122	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.0833
p.P253S	ACH-000790	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.5641
p.P916L	ACH-000904	Lung Cancer	CCLE	PPGY	ITCH	912:915	Mutation rewiring degron network	0.3056
p.P252H	ACH-000908	Gastric Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7694
p.R270H	ACH-000997	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	259:263	Mutation rewiring degron network	0.1389
p.E1548K	ACH-001402	Cervical Cancer	CCLE	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1111
p.E1548K	SW756	cervix	COSMIC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.1111
p.P1321R	ACH-001415	Bladder Cancer	CCLE	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.3056
p.S1574P	ACH-002183	Ovarian Cancer	CCLE	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.0556
p.S1574P	OVMIU	ovary	COSMIC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.0556
p.V1565F	ACH-002267	Leukemia	CCLE	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.3056
p.V1565F	LC4-1	haematopoietic and lymphoid tissue	COSMIC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.3056
p.Y1324H	ACH-002340	Neuroblastoma	CCLE	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.2222
p.Y1324H	NBsusSR	autonomic ganglia	COSMIC	DSGMYS	DEG_SCF_TRCP1_1	1315:1320	Mutation rewiring degron network	0.2222
p.P152T	NCI-H64	lung	COSMIC	PPAY	ITCH	145:148	Mutation rewiring degron network	0.2222
p.R391C	SNU-1040	large intestine	COSMIC	LARTPQPS	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.0556
p.P1556L	MIA-PaCa-2	pancreas	COSMIC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation altering degron motif	0.7582
p.R252K	EJM	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7237
p.D1573E	NCI-H810	lung	COSMIC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.0833
p.D1574E	NCI-H810	lung	COSMIC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation rewiring degron network	0.0556
p.P150A	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	145:148	Mutation rewiring degron network	0.2778
p.P150A	VMRC-LCD	lung	COSMIC	PPAY	ITCH	145:148	Mutation rewiring degron network	0.2778
p.S381F	COLO-792	skin	COSMIC	LARTPQPS	DEG_SCF_FBW7_1	374:381	Mutation altering degron motif	0.9093
p.S255I	OE21	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	252:256	Mutation altering degron motif	0.7341
p.P1072L	SK-MEL-28	skin	COSMIC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation substituting flanking lysine	0.1667
p.T918S	HT-1376	urinary tract	COSMIC	PPGY	ITCH	912:915	Mutation rewiring degron network	0.25
p.R1079H	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.25
p.P1073L	SK-MEL-28	skin	COSMIC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.0833
p.R1080H	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VGTSS	DEG_SPOP_SBC_1	1082:1086	Mutation rewiring degron network	0.2778
p.T919S	HT-1376	urinary tract	COSMIC	PPGY	ITCH	912:915	Mutation rewiring degron network	0.2222
p.P1557L	MIA-PaCa-2	pancreas	COSMIC	GPSAPVPPM	DEG_SIAH_1	1556:1564	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARID1A

UniProt ID: O14497

Entrez ID: 8289

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARID1A in