DegronMD

Uniprot ID: O14497

Source protein: AT-rich interactive domain-containing protein 1A

Source gene: ARID1A

Class: DEG_SCF_FBW7_1

Location: 374:381

E3 ligase: FBXW7

DEGRON score: 0.9939

ASA_SCORE: 99.675

COIL: 0.9596

CONS_SCORE: 0.3942

DSS_SCORE: 0.8964

HELIX: 0.0178

FCONS_SCORE: 1.0238

RIG_SCORE: 0.5509

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K389Q	TCGA-05-4427	LUAD	TCGA	LARTPQPS	DEG_SCF_FBW7_1	0.2222
p.K389Q	DO23666	LUAD	ICGC	LARTPQPS	DEG_SCF_FBW7_1	0.2222
p.P383S	TCGA-GF-A6C9	SKCM	TCGA	LARTPQPS	DEG_SCF_FBW7_1	0.2778
p.P383S	DO222572	MELA	ICGC	LARTPQPS	DEG_SCF_FBW7_1	0.2778
p.P383S	DO51254	SKCM	ICGC	LARTPQPS	DEG_SCF_FBW7_1	0.2778
p.D385Y	DO229025	LICA	ICGC	LARTPQPS	DEG_SCF_FBW7_1	0.2222
p.R391C	SNU-1040	large_intestine	COSMIC	LARTPQPS	DEG_SCF_FBW7_1	0.0556
p.S381F	COLO-792	skin	COSMIC	LARTPQPS	DEG_SCF_FBW7_1	0.9093

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SCF_FBW7_1	374:381	LARTPQPS	FBXW7	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons