DegronMD

Uniprot ID: O14497

Source protein: AT-rich interactive domain-containing protein 1A

Source gene: ARID1A

Class: DEG_SIAH_1

Location: 1556:1564

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.921

ASA_SCORE: 93.5889

COIL: 0.9781

CONS_SCORE: 0.5065

DSS_SCORE: 0.7648

HELIX: 0.0103

FCONS_SCORE: 1.1792

RIG_SCORE: 0.5078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1563T	TCGA-66-2727	LUSC	TCGA	GPSAPVPPM	DEG_SIAH_1	0.7031
p.P1563T	DO26478	LUSC	ICGC	GPSAPVPPM	DEG_SIAH_1	0.7031
p.G1549D	TCGA-AP-A0LM	UCEC	TCGA	GPSAPVPPM	DEG_SIAH_1	0.1389
p.G1549D	DO43306	UCEC	ICGC	GPSAPVPPM	DEG_SIAH_1	0.1389
p.R1566S	TCGA-AP-A1E1	UCEC	TCGA	GPSAPVPPM	DEG_SIAH_1	0.2778
p.R1566S	DO43226	UCEC	ICGC	GPSAPVPPM	DEG_SIAH_1	0.2778
p.G1549V	TCGA-BR-4184	STAD	TCGA	GPSAPVPPM	DEG_SIAH_1	0.1389
p.G1549V	DO38328	STAD	ICGC	GPSAPVPPM	DEG_SIAH_1	0.1389
p.R1551H	TCGA-KK-A59V	PRAD	TCGA	GPSAPVPPM	DEG_SIAH_1	0.1944
p.R1551H	TCGA-PG-A917	UCEC	TCGA	GPSAPVPPM	DEG_SIAH_1	0.1944
p.R1551H	DO51346	PRAD	ICGC	GPSAPVPPM	DEG_SIAH_1	0.1944
p.R1551H	DO52424	UCEC	ICGC	GPSAPVPPM	DEG_SIAH_1	0.1944
p.P1553S	DO229004	LICA	ICGC	GPSAPVPPM	DEG_SIAH_1	0.25
p.V1561L	DO23164	LINC	ICGC	GPSAPVPPM	DEG_SIAH_1	0.6765
p.P1562L	DO220851	MELA	ICGC	GPSAPVPPM	DEG_SIAH_1	0.6471
p.P1553L	DO228017	SKCA	ICGC	GPSAPVPPM	DEG_SIAH_1	0.25
p.E1560D	DO41758	UCEC	ICGC	GPSAPVPPM	DEG_SIAH_1	0.6758
p.E1548K	ACH-001402	Cervical Cancer	CCLE	GPSAPVPPM	DEG_SIAH_1	0.1111
p.E1548K	SW756	cervix	COSMIC	GPSAPVPPM	DEG_SIAH_1	0.1111
p.S1574P	ACH-002183	Ovarian Cancer	CCLE	GPSAPVPPM	DEG_SIAH_1	0.0556
p.S1574P	OVMIU	ovary	COSMIC	GPSAPVPPM	DEG_SIAH_1	0.0556
p.V1565F	ACH-002267	Leukemia	CCLE	GPSAPVPPM	DEG_SIAH_1	0.3056
p.V1565F	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	GPSAPVPPM	DEG_SIAH_1	0.3056
p.P1556L	MIA-PaCa-2	pancreas	COSMIC	GPSAPVPPM	DEG_SIAH_1	0.7582
p.D1573E	NCI-H810	lung	COSMIC	GPSAPVPPM	DEG_SIAH_1	0.0833
p.D1574E	NCI-H810	lung	COSMIC	GPSAPVPPM	DEG_SIAH_1	0.0556
p.P1557L	MIA-PaCa-2	pancreas	COSMIC	GPSAPVPPM	DEG_SIAH_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SIAH_1	1556:1564	GPSAPVPPM	SIAH1,SIAH2,SIAH3	0.921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GPSAPVPPM

Degron related mutations and impact score

Drug responses associated with ARID1A mutations

All proteins holding degron of GPSAPVPPM