DegronMD

Uniprot ID: O14497

Source protein: AT-rich interactive domain-containing protein 1A

Source gene: ARID1A

Class: DEG_SPOP_SBC_1

Location: 1147:1151

E3 ligase: SPOP

DEGRON score: 0.9731

ASA_SCORE: 79.52

COIL: 0.9436

CONS_SCORE: 0.4325

DSS_SCORE: 0.8659

HELIX: 0.033

FCONS_SCORE: 0.9754

RIG_SCORE: 0.5181

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1154T	TCGA-EY-A1GF	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.25
p.M1154T	DO41704	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.25
p.M1154I	DO227987	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.25
p.E1156G	DO23490	LINC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1944
p.G1139V	DO45819	NBL	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1111
p.S1151N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PQSTS	DEG_SPOP_SBC_1	0.7069
p.S1151N	ACH-001737	Leukemia	CCLE	PQSTS	DEG_SPOP_SBC_1	0.7069
p.S1151N	ACH-002222	Leukemia	CCLE	PQSTS	DEG_SPOP_SBC_1	0.7069
p.S1151N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1147:1151	PQSTS	SPOP	0.9731	More...
P07202	Thyroid peroxidase	DEG_SPOP_SBC_1	245:249	PQSTS	SPOP	0.8902	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	1112:1116	PQSTS	SPOP	0.9975	More...
Q14114	Low-density lipoprotein receptor-related protein 8	DEG_SPOP_SBC_1	738:742	PQSTS	SPOP	0.7494	More...
Q92817	Envoplakin	DEG_SPOP_SBC_1	1806:1810	PQSTS	SPOP	0.681	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	DEG_SPOP_SBC_1	279:283	PQSTS	SPOP	0.9473	More...
Q9NU22	Midasin	DEG_SPOP_SBC_1	1546:1550	PQSTS	SPOP	0.568	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	804:808	PQSTS	SPOP	0.9041	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	502:506	PQSTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons