DegronMD - Q92817(EVPL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1804L	TCGA-19-1787	GBM	TCGA	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation rewiring degron network	0.2778
p.P1806A	TCGA-A8-A06X	BRCA	TCGA	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation altering degron motif	0.6392
p.A370T	TCGA-AX-A2HC	UCEC	TCGA	NLDAKYSPAP	CBL_PTK	355:364	Mutation rewiring degron network	0.1667
p.A370T	DO41572	UCEC	ICGC	NLDAKYSPAP	CBL_PTK	355:364	Mutation rewiring degron network	0.1667
p.G366A	TCGA-BG-A221	UCEC	TCGA	NLDAKYSPAP	CBL_PTK	355:364	Mutation rewiring degron network	0.2778
p.G366A	DO42384	UCEC	ICGC	NLDAKYSPAP	CBL_PTK	355:364	Mutation rewiring degron network	0.2778
p.G366A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NLDAKYSPAP	CBL_PTK	355:364	Mutation rewiring degron network	0.2778
p.G366A	SIDM01263	T-Lymphoblastic Leukemia	GDSC	NLDAKYSPAP	CBL_PTK	355:364	Mutation rewiring degron network	0.2778
p.P1806S	TCGA-BR-6452	STAD	TCGA	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation altering degron motif	0.6752
p.P1806S	DO38404	STAD	ICGC	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation altering degron motif	0.6752
p.S1803F	TCGA-DQ-5625	HNSC	TCGA	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation rewiring degron network	0.25
p.S1803F	DO15414	HNSC	ICGC	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation rewiring degron network	0.25
p.Q430K	TCGA-ES-A2HT	LIHC	TCGA	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.2778
p.Q430K	DO22956	LIHC	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.2778
p.Q433R	DO229010	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1944
p.Q433R	DO229013	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1944
p.Q433R	DO229016	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1944
p.Q433R	DO229003	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1944
p.Q433R	DO229005	COCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1944
p.Q433R	DO230538	LUSC	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1944
p.R436W	DO233823	GACA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.R436W	DO220847	MELA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.L1820R	DO233937	GACA	ICGC	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation rewiring degron network	0.0556
p.A370D	DO229008	LICA	ICGC	NLDAKYSPAP	CBL_PTK	355:364	Mutation rewiring degron network	0.1667
p.R436G	DO233293	NACA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.G434D	DO232761	PBCA	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1667
p.R436Q	DO232998	PEME	ICGC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.G1804V	DO37707	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation rewiring degron network	0.2778
p.S346N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NLDAKYSPAP	CBL_PTK	355:364	Mutation blocking phosphorylation signal	0.5278
p.S346N	ACH-000995	Leukemia	CCLE	NLDAKYSPAP	CBL_PTK	355:364	Mutation blocking phosphorylation signal	0.5278
p.S346N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NLDAKYSPAP	CBL_PTK	355:364	Mutation blocking phosphorylation signal	0.5278
p.T1806S	SIDM00934	Pancreatic Carcinoma	GDSC	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation altering degron motif	0.7116
p.T1806S	CAPAN-1	pancreas	COSMIC	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation altering degron motif	0.7116
p.P415S	SIDM00997	Thyroid Gland Carcinoma	GDSC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.P415S	SIDM00543	Melanoma	GDSC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.P415S	SIDM01782	Oral Cavity Carcinoma	GDSC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.P415S	8305C	thyroid	COSMIC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.P415S	GAK	skin	COSMIC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation rewiring degron network	0.1111
p.P364S	SIDM00864	Cervical Carcinoma	GDSC	NLDAKYSPAP	CBL_PTK	355:364	Mutation altering degron motif	0.6752
p.P364S	ACH-001341	Cervical Cancer	CCLE	NLDAKYSPAP	CBL_PTK	355:364	Mutation altering degron motif	0.6752
p.P364S	DoTc2-4510	cervix	COSMIC	NLDAKYSPAP	CBL_PTK	355:364	Mutation altering degron motif	0.6752
p.W424L	SIDM00167	Head and Neck Carcinoma	GDSC	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation altering degron motif	0.5904
p.W424L	ACH-000715	Head and Neck Cancer	CCLE	DWDSGE	DEG_Kelch_Keap1_1	423:428	Mutation altering degron motif	0.5904
p.S1813C	ACH-000181	Head and Neck Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation rewiring degron network	0.25
p.S1813C	SCC-9	upper aerodigestive tract	COSMIC	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation rewiring degron network	0.25
p.T1809I	ACH-000700	Lung Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation altering degron motif	0.7078
p.P1800L	ACH-001484	Leukemia	CCLE	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation rewiring degron network	0.1667
p.P1800L	ACH-001485	Leukemia	CCLE	PQSTS	DEG_SPOP_SBC_1	1806:1810	Mutation rewiring degron network	0.1667
p.S354F	ACH-001568	Skin Cancer	CCLE	NLDAKYSPAP	CBL_PTK	355:364	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EVPL

UniProt ID: Q92817

Entrez ID: 2125

Protein name: Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EVPL in