DegronMD

Uniprot ID: Q92817

Source protein: Envoplakin

Source gene: EVPL

Class: DEG_SPOP_SBC_1

Location: 1806:1810

E3 ligase: SPOP

DEGRON score: 0.681

ASA_SCORE: 75.96

COIL: 0.7264

CONS_SCORE: 0.376

DSS_SCORE: 0.3581

HELIX: 0.106

FCONS_SCORE: 0.9594

RIG_SCORE: 0.6569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1804L	TCGA-19-1787	GBM	TCGA	PQSTS	DEG_SPOP_SBC_1	0.2778
p.P1806A	TCGA-A8-A06X	BRCA	TCGA	PQSTS	DEG_SPOP_SBC_1	0.6392
p.P1806S	TCGA-BR-6452	STAD	TCGA	PQSTS	DEG_SPOP_SBC_1	0.6752
p.P1806S	DO38404	STAD	ICGC	PQSTS	DEG_SPOP_SBC_1	0.6752
p.S1803F	TCGA-DQ-5625	HNSC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.25
p.S1803F	DO15414	HNSC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.25
p.L1820R	DO233937	GACA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0556
p.G1804V	DO37707	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	0.2778
p.T1806S	SIDM00934	Pancreatic Carcinoma	GDSC	PQSTS	DEG_SPOP_SBC_1	0.7116
p.T1806S	CAPAN-1	pancreas	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.7116
p.S1813C	ACH-000181	Head and Neck Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	0.25
p.S1813C	SCC-9	upper_aerodigestive_tract	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.25
p.T1809I	ACH-000700	Lung Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	0.7078
p.P1800L	ACH-001484	Leukemia	CCLE	PQSTS	DEG_SPOP_SBC_1	0.1667
p.P1800L	ACH-001485	Leukemia	CCLE	PQSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1147:1151	PQSTS	SPOP	0.9731	More...
P07202	Thyroid peroxidase	DEG_SPOP_SBC_1	245:249	PQSTS	SPOP	0.8902	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	1112:1116	PQSTS	SPOP	0.9975	More...
Q14114	Low-density lipoprotein receptor-related protein 8	DEG_SPOP_SBC_1	738:742	PQSTS	SPOP	0.7494	More...
Q92817	Envoplakin	DEG_SPOP_SBC_1	1806:1810	PQSTS	SPOP	0.681	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	DEG_SPOP_SBC_1	279:283	PQSTS	SPOP	0.9473	More...
Q9NU22	Midasin	DEG_SPOP_SBC_1	1546:1550	PQSTS	SPOP	0.568	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	804:808	PQSTS	SPOP	0.9041	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	502:506	PQSTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons