DegronMD - P07202(TPO)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A168T	TCGA-12-3648	GBM	TCGA	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	TCGA-K4-A4AC	BLCA	TCGA	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	TCGA-KB-A93G	STAD	TCGA	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	DO542	BLCA	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	DO52511	EOPC	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	DO12604	GBM	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	DO222335	STAD	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	SIDM00680	Colorectal Carcinoma	GDSC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	SIDM00520	Mesothelioma	GDSC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	LS-180	large intestine	COSMIC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.A168T	H2818	pleura	COSMIC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0556
p.G184S	TCGA-17-Z003	LUAD	TCGA	PPVY	ITCH	178:181	Mutation rewiring degron network	0.25
p.G184S	DO36969	READ	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.25
p.D238N	TCGA-32-4211	GBM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.25
p.D238N	TCGA-32-4211	GBM	TCGA	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1389
p.D238N	TCGA-FI-A2D5	UCEC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.25
p.D238N	TCGA-FI-A2D5	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1389
p.D238N	DO13647	GBM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.25
p.D238N	DO13647	GBM	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1389
p.D238N	DO41331	UCEC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.25
p.D238N	DO41331	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1389
p.Y181H	TCGA-44-5644	LUAD	TCGA	PPVY	ITCH	178:181	Mutation altering degron motif	0.7229
p.Y181H	DO25153	LUAD	ICGC	PPVY	ITCH	178:181	Mutation altering degron motif	0.7229
p.T171M	TCGA-76-4926	GBM	TCGA	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1389
p.T171M	DO12478	GBM	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1389
p.T171M	DO49118	PACA	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1389
p.D258Y	TCGA-78-7155	LUAD	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.0556
p.D258Y	TCGA-78-7155	LUAD	TCGA	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.D258Y	DO23590	LUAD	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.0556
p.D258Y	DO23590	LUAD	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.D240Y	TCGA-90-A59Q	LUSC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.3056
p.D240Y	TCGA-90-A59Q	LUSC	TCGA	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.D240Y	DO50103	LUSC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.3056
p.D240Y	DO50103	LUSC	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.G190S	TCGA-A5-A1OF	UCEC	TCGA	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0833
p.G190S	DO42568	UCEC	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0833
p.Q187K	TCGA-BA-6869	HNSC	TCGA	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.Q187K	DO14250	HNSC	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.D258H	TCGA-BA-6871	HNSC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.0556
p.D258H	TCGA-BA-6871	HNSC	TCGA	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.D258H	DO15254	HNSC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.0556
p.D258H	DO15254	HNSC	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.A242T	TCGA-BR-4292	STAD	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.6028
p.A242T	TCGA-CV-6937	HNSC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.6028
p.A242T	TCGA-G4-6302	COAD	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.6028
p.A242T	DO8778	COAD	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.6028
p.A242T	DO14155	HNSC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.6028
p.A242T	DO38495	STAD	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.6028
p.G254W	TCGA-D3-A2JB	SKCM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1667
p.G254W	TCGA-D3-A2JB	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.G254W	DO47607	SKCM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1667
p.G254W	DO47607	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.R175Q	TCGA-D6-6516	HNSC	TCGA	PPVY	ITCH	178:181	Mutation rewiring degron network	0.25
p.R175Q	DO15623	HNSC	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.25
p.G255R	TCGA-D9-A4Z3	SKCM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1389
p.G255R	TCGA-D9-A4Z3	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1667
p.G255R	DO47555	SKCM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1389
p.G255R	DO47555	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1667
p.P178S	TCGA-EE-A29E	SKCM	TCGA	PPVY	ITCH	178:181	Mutation altering degron motif	0.6752
p.P178S	DO37831	SKCM	ICGC	PPVY	ITCH	178:181	Mutation altering degron motif	0.6752
p.W233C	TCGA-EE-A2M5	SKCM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1111
p.W233C	DO37425	SKCM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1111
p.G254R	TCGA-FA-A4XK	DLBC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1667
p.G254R	TCGA-FA-A4XK	DLBC	TCGA	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.G254R	TCGA-WS-AB45	COAD	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1667
p.G254R	TCGA-WS-AB45	COAD	TCGA	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.G254R	DO51734	COAD	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1667
p.G254R	DO51734	COAD	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.G254R	DO219886	DLBC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1667
p.G254R	DO219886	DLBC	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.G234R	TCGA-FW-A3R5	SKCM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1389
p.G234R	DO37406	SKCM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1389
p.R189Q	DO48372	BLCA	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1111
p.L370F	DO51607	CESC	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.2778
p.R361L	DO230334	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation altering degron motif	0.8428
p.R361L	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation altering degron motif	0.8428
p.A257S	DO227999	COCA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.0833
p.A257S	DO227999	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1111
p.A257S	DO229505	LAML	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.0833
p.A257S	DO229505	LAML	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1111
p.A373S	DO229010	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1944
p.A373S	DO229013	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1944
p.A373S	DO229016	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1944
p.A373S	DO229003	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1944
p.A373S	DO229005	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1944
p.A373S	DO229346	LAML	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1944
p.S247I	DO233155	GACA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.623
p.S247I	DO233155	GACA	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.7341
p.F243V	DO233155	GACA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.5957
p.A354V	DO233913	GACA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1667
p.R361S	DO14250	HNSC	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation altering degron motif	0.7427
p.S186C	DO231973	LICA	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1944
p.A374T	DO50970	LICA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1667
p.Q377H	DO23744	LUAD	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.0833
p.R351L	DO26710	LUSC	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.0833
p.S169P	DO228316	MALY	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0833
p.G234E	DO220899	MELA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1389
p.G255V	DO233295	NACA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.1389
p.G255V	DO233295	NACA	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1667
p.A242V	DO50685	ORCA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.5825
p.A242V	SIDM01770	Gastric Carcinoma	GDSC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.5825
p.A242V	ACH-000908	Gastric Cancer	CCLE	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.5825
p.R361H	DO232054	ORCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation altering degron motif	0.8244
p.R351H	DO33200	PACA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.0833
p.D240N	DO233033	PEME	ICGC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.3056
p.D240N	DO233033	PEME	ICGC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.D240N	SIDM00619	Thyroid Gland Carcinoma	GDSC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.3056
p.D240N	SIDM00619	Thyroid Gland Carcinoma	GDSC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.D240N	ACH-002397	Thyroid Cancer	CCLE	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.3056
p.D240N	ACH-002397	Thyroid Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.D240N	KMH-2	thyroid	COSMIC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation rewiring degron network	0.3056
p.D240N	KMH-2	thyroid	COSMIC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.V180I	DO229446	SKCA	ICGC	PPVY	ITCH	178:181	Mutation altering degron motif	0.5965
p.P377S	DO37607	SKCM	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.0833
p.G359E	DO38099	SKCM	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.3056
p.L356P	DO229272	THCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.2222
p.P365T	DO229221	THCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation altering degron motif	0.5919
p.E171K	DO50076	UCEC	ICGC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1389
p.T355A	DO41020	UCEC	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1944
p.A371V	SIDM02049	Pancreatic Carcinoma	GDSC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.25
p.R355C	SIDM02021	Esophageal Carcinoma	GDSC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1944
p.P179T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPVY	ITCH	178:181	Mutation altering degron motif	0.7031
p.P179T	ACH-000924	Lung Cancer	CCLE	PPVY	ITCH	178:181	Mutation altering degron motif	0.7031
p.P179T	NCI-H2172	lung	COSMIC	PPVY	ITCH	178:181	Mutation altering degron motif	0.7031
p.L173M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1944
p.L173M	ACH-000924	Lung Cancer	CCLE	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1944
p.L173M	NCI-H2172	lung	COSMIC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1944
p.T244A	SIDM01164	Glioma	GDSC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.7139
p.T244A	ACH-000883	Brain Cancer	CCLE	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.7139
p.T244A	SW1783	central nervous system	COSMIC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.7139
p.A172S	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.A172S	ACH-000886	Lung Cancer	CCLE	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.A172S	NCI-H2009	lung	COSMIC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.Q187R	SIDM01608	Endometrial Carcinoma	GDSC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.Q187R	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.S169Y	ACH-000870	Lung Cancer	CCLE	PPVY	ITCH	178:181	Mutation rewiring degron network	0.0833
p.R351C	ACH-001145	Ovarian Cancer	CCLE	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.0833
p.A376V	ACH-001669	Leukemia	CCLE	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.1111
p.P245L	ACH-002396	Bone Cancer	CCLE	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.7582
p.P245L	ACH-002396	Bone Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.7582
p.P245L	Sarc9371	bone	COSMIC	IAFTPQST	DEG_SCF_FBW7_1	241:248	Mutation altering degron motif	0.7582
p.P245L	Sarc9371	bone	COSMIC	PQSTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.7582
p.T172A	IGROV-1	ovary	COSMIC	PPVY	ITCH	178:181	Mutation rewiring degron network	0.1667
p.G359V	U-698-M	haematopoietic and lymphoid tissue	COSMIC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.3056
p.R358H	HDQ-P1	breast	COSMIC	GRAYLPFVP	DEG_APCC_DBOX_1	360:368	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPO

UniProt ID: P07202

Entrez ID: 7173

Protein name: Thyroid peroxidase (TPO) (EC 1.11.1.8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPO in