DegronMD

Uniprot ID: P07202

Source protein: Thyroid peroxidase

Source gene: TPO

Class: DEG_APCC_DBOX_1

Location: 360:368

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9941

ASA_SCORE: 50.6889

COIL: 0.86

CONS_SCORE: 0.4904

DSS_SCORE: 0.3413

HELIX: 0.0144

FCONS_SCORE: 1.3292

RIG_SCORE: 0.7301

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L370F	DO51607	CESC	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.2778
p.R361L	DO230334	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.8428
p.R361L	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	GRAYLPFVP	DEG_APCC_DBOX_1	0.8428
p.A373S	DO229010	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1944
p.A373S	DO229013	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1944
p.A373S	DO229016	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1944
p.A373S	DO229003	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1944
p.A373S	DO229005	COCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1944
p.A373S	DO229346	LAML	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1944
p.A354V	DO233913	GACA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1667
p.R361S	DO14250	HNSC	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.7427
p.A374T	DO50970	LICA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1667
p.Q377H	DO23744	LUAD	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.0833
p.R351L	DO26710	LUSC	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.0833
p.R361H	DO232054	ORCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.8244
p.R351H	DO33200	PACA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.0833
p.P377S	DO37607	SKCM	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.0833
p.G359E	DO38099	SKCM	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.3056
p.L356P	DO229272	THCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.2222
p.P365T	DO229221	THCA	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.5919
p.T355A	DO41020	UCEC	ICGC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1944
p.A371V	SIDM02049	Pancreatic Carcinoma	GDSC	GRAYLPFVP	DEG_APCC_DBOX_1	0.25
p.R355C	SIDM02021	Esophageal Carcinoma	GDSC	GRAYLPFVP	DEG_APCC_DBOX_1	0.1944
p.R351C	ACH-001145	Ovarian Cancer	CCLE	GRAYLPFVP	DEG_APCC_DBOX_1	0.0833
p.A376V	ACH-001669	Leukemia	CCLE	GRAYLPFVP	DEG_APCC_DBOX_1	0.1111
p.G359V	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	GRAYLPFVP	DEG_APCC_DBOX_1	0.3056
p.R358H	HDQ-P1	breast	COSMIC	GRAYLPFVP	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07202	Thyroid peroxidase	DEG_APCC_DBOX_1	360:368	GRAYLPFVP	APC,CDC20,FZR1	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRAYLPFVP

Degron related mutations and impact score

Drug responses associated with TPO mutations

All proteins holding degron of GRAYLPFVP