DegronMD

Uniprot ID: P07202

Source protein: Thyroid peroxidase

Source gene: TPO

Class: DEG_SCF_FBW7_1

Location: 241:248

E3 ligase: FBXW7

DEGRON score: 0.841

ASA_SCORE: 54.075

COIL: 0.7858

CONS_SCORE: 0.5011

DSS_SCORE: 0.3028

HELIX: 0.1453

FCONS_SCORE: 0.9418

RIG_SCORE: 0.7789

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D238N	TCGA-32-4211	GBM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.25
p.D238N	TCGA-FI-A2D5	UCEC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.25
p.D238N	DO13647	GBM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.25
p.D238N	DO41331	UCEC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.25
p.D258Y	TCGA-78-7155	LUAD	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.0556
p.D258Y	DO23590	LUAD	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.0556
p.D240Y	TCGA-90-A59Q	LUSC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.3056
p.D240Y	DO50103	LUSC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.3056
p.D258H	TCGA-BA-6871	HNSC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.0556
p.D258H	DO15254	HNSC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.0556
p.A242T	TCGA-BR-4292	STAD	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.6028
p.A242T	TCGA-CV-6937	HNSC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.6028
p.A242T	TCGA-G4-6302	COAD	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.6028
p.A242T	DO8778	COAD	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.6028
p.A242T	DO14155	HNSC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.6028
p.A242T	DO38495	STAD	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.6028
p.G254W	TCGA-D3-A2JB	SKCM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.1667
p.G254W	DO47607	SKCM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.1667
p.G255R	TCGA-D9-A4Z3	SKCM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.1389
p.G255R	DO47555	SKCM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.1389
p.W233C	TCGA-EE-A2M5	SKCM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.1111
p.W233C	DO37425	SKCM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.1111
p.G254R	TCGA-FA-A4XK	DLBC	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.1667
p.G254R	TCGA-WS-AB45	COAD	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.1667
p.G254R	DO51734	COAD	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.1667
p.G254R	DO219886	DLBC	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.1667
p.G234R	TCGA-FW-A3R5	SKCM	TCGA	IAFTPQST	DEG_SCF_FBW7_1	0.1389
p.G234R	DO37406	SKCM	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.1389
p.A257S	DO227999	COCA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.0833
p.A257S	DO229505	LAML	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.0833
p.S247I	DO233155	GACA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.623
p.F243V	DO233155	GACA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.5957
p.G234E	DO220899	MELA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.1389
p.G255V	DO233295	NACA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.1389
p.A242V	DO50685	ORCA	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.5825
p.A242V	SIDM01770	Gastric Carcinoma	GDSC	IAFTPQST	DEG_SCF_FBW7_1	0.5825
p.A242V	ACH-000908	Gastric Cancer	CCLE	IAFTPQST	DEG_SCF_FBW7_1	0.5825
p.D240N	DO233033	PEME	ICGC	IAFTPQST	DEG_SCF_FBW7_1	0.3056
p.D240N	SIDM00619	Thyroid Gland Carcinoma	GDSC	IAFTPQST	DEG_SCF_FBW7_1	0.3056
p.D240N	ACH-002397	Thyroid Cancer	CCLE	IAFTPQST	DEG_SCF_FBW7_1	0.3056
p.D240N	KMH-2	thyroid	COSMIC	IAFTPQST	DEG_SCF_FBW7_1	0.3056
p.T244A	SIDM01164	Glioma	GDSC	IAFTPQST	DEG_SCF_FBW7_1	0.7139
p.T244A	ACH-000883	Brain Cancer	CCLE	IAFTPQST	DEG_SCF_FBW7_1	0.7139
p.T244A	SW1783	central_nervous_system	COSMIC	IAFTPQST	DEG_SCF_FBW7_1	0.7139
p.P245L	ACH-002396	Bone Cancer	CCLE	IAFTPQST	DEG_SCF_FBW7_1	0.7582
p.P245L	Sarc9371	bone	COSMIC	IAFTPQST	DEG_SCF_FBW7_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAFTPQST

Degron related mutations and impact score

Drug responses associated with TPO mutations

All proteins holding degron of IAFTPQST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07202	Thyroid peroxidase	DEG_SCF_FBW7_1	241:248	IAFTPQST	FBXW7	0.841	More...