DegronMD

Uniprot ID: P07202

Source protein: Thyroid peroxidase

Source gene: TPO

Class: DEG_SPOP_SBC_1

Location: 245:249

E3 ligase: SPOP

DEGRON score: 0.8902

ASA_SCORE: 56.66

COIL: 0.8518

CONS_SCORE: 0.3927

DSS_SCORE: 0.3362

HELIX: 0.0928

FCONS_SCORE: 0.7305

RIG_SCORE: 0.7419

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D238N	TCGA-32-4211	GBM	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1389
p.D238N	TCGA-FI-A2D5	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1389
p.D238N	DO13647	GBM	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1389
p.D238N	DO41331	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1389
p.D258Y	TCGA-78-7155	LUAD	TCGA	PQSTS	DEG_SPOP_SBC_1	0.0833
p.D258Y	DO23590	LUAD	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.D240Y	TCGA-90-A59Q	LUSC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1944
p.D240Y	DO50103	LUSC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1944
p.D258H	TCGA-BA-6871	HNSC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.0833
p.D258H	DO15254	HNSC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.G254W	TCGA-D3-A2JB	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1944
p.G254W	DO47607	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1944
p.G255R	TCGA-D9-A4Z3	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1667
p.G255R	DO47555	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1667
p.G254R	TCGA-FA-A4XK	DLBC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1944
p.G254R	TCGA-WS-AB45	COAD	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1944
p.G254R	DO51734	COAD	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1944
p.G254R	DO219886	DLBC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1944
p.A257S	DO227999	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1111
p.A257S	DO229505	LAML	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1111
p.S247I	DO233155	GACA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.7341
p.G255V	DO233295	NACA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1667
p.D240N	DO233033	PEME	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1944
p.D240N	SIDM00619	Thyroid Gland Carcinoma	GDSC	PQSTS	DEG_SPOP_SBC_1	0.1944
p.D240N	ACH-002397	Thyroid Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	0.1944
p.D240N	KMH-2	thyroid	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.1944
p.P245L	ACH-002396	Bone Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	0.7582
p.P245L	Sarc9371	bone	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1147:1151	PQSTS	SPOP	0.9731	More...
P07202	Thyroid peroxidase	DEG_SPOP_SBC_1	245:249	PQSTS	SPOP	0.8902	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	1112:1116	PQSTS	SPOP	0.9975	More...
Q14114	Low-density lipoprotein receptor-related protein 8	DEG_SPOP_SBC_1	738:742	PQSTS	SPOP	0.7494	More...
Q92817	Envoplakin	DEG_SPOP_SBC_1	1806:1810	PQSTS	SPOP	0.681	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	DEG_SPOP_SBC_1	279:283	PQSTS	SPOP	0.9473	More...
Q9NU22	Midasin	DEG_SPOP_SBC_1	1546:1550	PQSTS	SPOP	0.568	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	804:808	PQSTS	SPOP	0.9041	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	502:506	PQSTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQSTS

Degron related mutations and impact score

Drug responses associated with TPO mutations

All proteins holding degron of PQSTS