DegronMD - Q9NU22(MDN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1551C	TCGA-98-A53I	LUSC	TCGA	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.R1551C	TCGA-WP-A9GB	SARC	TCGA	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.R1551C	DO219182	LUSC	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.R1551C	DO220307	SARC	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.D1553Y	TCGA-AX-A05Z	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.25
p.D1553Y	DO40884	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.25
p.R1537I	TCGA-B5-A0JY	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.0833
p.R1537I	DO43041	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.0833
p.E1542K	TCGA-BB-7870	HNSC	TCGA	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.2222
p.E1542K	DO14378	HNSC	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.2222
p.E1552K	TCGA-BL-A3JM	BLCA	TCGA	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.2778
p.E1552K	DO532	BLCA	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.2778
p.E5023Q	TCGA-CN-6018	HNSC	TCGA	EDSDTEEQVPEA	DEG_COP1_1	5013:5024	Mutation altering degron motif	0.6744
p.E5023Q	DO15575	HNSC	ICGC	EDSDTEEQVPEA	DEG_COP1_1	5013:5024	Mutation altering degron motif	0.6744
p.R1539Q	TCGA-D1-A17Q	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.1389
p.R1539Q	DO228993	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.1389
p.R1539Q	DO41903	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.1389
p.S1559N	DO229010	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.0833
p.S1559N	DO229013	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.0833
p.S1559N	DO229016	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.0833
p.S1559N	DO229003	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.0833
p.S1559N	DO229005	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.0833
p.R1539W	DO233668	GACA	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.1389
p.T5017K	DO229015	LICA	ICGC	EDSDTEEQVPEA	DEG_COP1_1	5013:5024	Mutation altering degron motif	0.7306
p.P1546S	DO222402	MELA	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation altering degron motif	0.6752
p.T1549A	DO38404	STAD	ICGC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation altering degron motif	0.7139
p.R1551H	SIDM00578	Neuroblastoma	GDSC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.R1551H	SIDM00901	Endometrial Carcinoma	GDSC	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.R1551H	ACH-000804	Neuroblastoma	CCLE	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.R1551H	ACH-000940	Endometrial/Uterine Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.E5013K	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	EDSDTEEQVPEA	DEG_COP1_1	5013:5024	Mutation altering degron motif	0.7022
p.E5013K	ACH-000452	Esophageal Cancer	CCLE	EDSDTEEQVPEA	DEG_COP1_1	5013:5024	Mutation altering degron motif	0.7022
p.E5013K	TE-8	oesophagus	COSMIC	EDSDTEEQVPEA	DEG_COP1_1	5013:5024	Mutation altering degron motif	0.7022
p.E5019K	ACH-001148	Lymphoma	CCLE	EDSDTEEQVPEA	DEG_COP1_1	5013:5024	Mutation altering degron motif	0.591

Kaplan plot for MDN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MDN1

UniProt ID: Q9NU22

Entrez ID: 23195

Protein name: Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MDN1 in