DegronMD

Uniprot ID: Q9NU22

Source protein: Midasin

Source gene: MDN1

Class: DEG_COP1_1

Location: 5013:5024

E3 ligase: COP1

DEGRON score: 0.9452

ASA_SCORE: 107.2417

COIL: 0.5961

CONS_SCORE: 0.31

DSS_SCORE: 0.8833

HELIX: 0.4027

FCONS_SCORE: 1.0963

RIG_SCORE: 0.6558

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E5023Q	TCGA-CN-6018	HNSC	TCGA	EDSDTEEQVPEA	DEG_COP1_1	0.6744
p.E5023Q	DO15575	HNSC	ICGC	EDSDTEEQVPEA	DEG_COP1_1	0.6744
p.T5017K	DO229015	LICA	ICGC	EDSDTEEQVPEA	DEG_COP1_1	0.7306
p.E5013K	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	EDSDTEEQVPEA	DEG_COP1_1	0.7022
p.E5013K	ACH-000452	Esophageal Cancer	CCLE	EDSDTEEQVPEA	DEG_COP1_1	0.7022
p.E5013K	TE-8	oesophagus	COSMIC	EDSDTEEQVPEA	DEG_COP1_1	0.7022
p.E5019K	ACH-001148	Lymphoma	CCLE	EDSDTEEQVPEA	DEG_COP1_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NU22	Midasin	DEG_COP1_1	5013:5024	EDSDTEEQVPEA	COP1	0.9452	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons