DegronMD

Uniprot ID: Q9NU22

Source protein: Midasin

Source gene: MDN1

Class: DEG_SPOP_SBC_1

Location: 1546:1550

E3 ligase: SPOP

DEGRON score: 0.568

ASA_SCORE: 65.78

COIL: 0.9174

CONS_SCORE: 0.4639

DSS_SCORE: 0.2381

HELIX: 0.031

FCONS_SCORE: 0.7507

RIG_SCORE: 0.788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1551C	TCGA-98-A53I	LUSC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.3056
p.R1551C	TCGA-WP-A9GB	SARC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.3056
p.R1551C	DO219182	LUSC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.3056
p.R1551C	DO220307	SARC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.3056
p.D1553Y	TCGA-AX-A05Z	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.25
p.D1553Y	DO40884	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.25
p.R1537I	TCGA-B5-A0JY	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.0833
p.R1537I	DO43041	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.E1542K	TCGA-BB-7870	HNSC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.2222
p.E1542K	DO14378	HNSC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.2222
p.E1552K	TCGA-BL-A3JM	BLCA	TCGA	PQSTS	DEG_SPOP_SBC_1	0.2778
p.E1552K	DO532	BLCA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.2778
p.R1539Q	TCGA-D1-A17Q	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1389
p.R1539Q	DO228993	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1389
p.R1539Q	DO41903	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1389
p.S1559N	DO229010	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.S1559N	DO229013	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.S1559N	DO229016	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.S1559N	DO229003	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.S1559N	DO229005	COCA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.R1539W	DO233668	GACA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1389
p.P1546S	DO222402	MELA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.6752
p.T1549A	DO38404	STAD	ICGC	PQSTS	DEG_SPOP_SBC_1	0.7139
p.R1551H	SIDM00578	Neuroblastoma	GDSC	PQSTS	DEG_SPOP_SBC_1	0.3056
p.R1551H	SIDM00901	Endometrial Carcinoma	GDSC	PQSTS	DEG_SPOP_SBC_1	0.3056
p.R1551H	ACH-000804	Neuroblastoma	CCLE	PQSTS	DEG_SPOP_SBC_1	0.3056
p.R1551H	ACH-000940	Endometrial/Uterine Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1147:1151	PQSTS	SPOP	0.9731	More...
P07202	Thyroid peroxidase	DEG_SPOP_SBC_1	245:249	PQSTS	SPOP	0.8902	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	1112:1116	PQSTS	SPOP	0.9975	More...
Q14114	Low-density lipoprotein receptor-related protein 8	DEG_SPOP_SBC_1	738:742	PQSTS	SPOP	0.7494	More...
Q92817	Envoplakin	DEG_SPOP_SBC_1	1806:1810	PQSTS	SPOP	0.681	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	DEG_SPOP_SBC_1	279:283	PQSTS	SPOP	0.9473	More...
Q9NU22	Midasin	DEG_SPOP_SBC_1	1546:1550	PQSTS	SPOP	0.568	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	804:808	PQSTS	SPOP	0.9041	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	502:506	PQSTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons