DegronMD

Uniprot ID: Q14114

Source protein: Low-density lipoprotein receptor-related protein 8

Source gene: LRP8

Class: DEG_SPOP_SBC_1

Location: 738:742

E3 ligase: SPOP

DEGRON score: 0.7494

ASA_SCORE: 81.74

COIL: 0.7862

CONS_SCORE: 0.5005

DSS_SCORE: 0.4671

HELIX: 0.0774

FCONS_SCORE: 0.9707

RIG_SCORE: 0.6914

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T749I	TCGA-DF-A2KU	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1389
p.T749I	DO223286	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1389
p.R736Q	SIDM00672	Hepatocellular Carcinoma	GDSC	PQSTS	DEG_SPOP_SBC_1	0.2778
p.E742D	ACH-000786	Lymphoma	CCLE	PQSTS	DEG_SPOP_SBC_1	0.6758
p.E742D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.6758
p.P743L	RO82-W-1	thyroid	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.3056
p.P743L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1147:1151	PQSTS	SPOP	0.9731	More...
P07202	Thyroid peroxidase	DEG_SPOP_SBC_1	245:249	PQSTS	SPOP	0.8902	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	1112:1116	PQSTS	SPOP	0.9975	More...
Q14114	Low-density lipoprotein receptor-related protein 8	DEG_SPOP_SBC_1	738:742	PQSTS	SPOP	0.7494	More...
Q92817	Envoplakin	DEG_SPOP_SBC_1	1806:1810	PQSTS	SPOP	0.681	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	DEG_SPOP_SBC_1	279:283	PQSTS	SPOP	0.9473	More...
Q9NU22	Midasin	DEG_SPOP_SBC_1	1546:1550	PQSTS	SPOP	0.568	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	804:808	PQSTS	SPOP	0.9041	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	502:506	PQSTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons