DegronMD - Q9HCK1(ZDBF2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V513I	TCGA-43-A474	LUSC	TCGA	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1389
p.V513I	DO45490	LUSC	ICGC	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1389
p.V216D	TCGA-49-AARQ	LUAD	TCGA	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0556
p.V216D	DO51189	LUAD	ICGC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0556
p.Q901P	TCGA-55-7576	LUAD	TCGA	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.1944
p.Q901P	DO24431	LUAD	ICGC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.1944
p.D499N	TCGA-55-8302	LUAD	TCGA	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.25
p.D499N	DO45312	LUAD	ICGC	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.25
p.S248L	TCGA-93-8067	LUAD	TCGA	VETTS	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7667
p.S248L	DO25113	LUAD	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7667
p.T205A	TCGA-B5-A3FA	UCEC	TCGA	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.7139
p.T205A	DO52402	UCEC	ICGC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.7139
p.E515D	TCGA-BR-8297	STAD	TCGA	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.E515D	DO38555	STAD	ICGC	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.P240R	TCGA-CC-A8HT	LIHC	TCGA	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2222
p.P240R	DO52187	LIHC	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2222
p.D214N	TCGA-DA-A1I0	SKCM	TCGA	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1111
p.D214N	DO37719	SKCM	ICGC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1111
p.D197N	TCGA-DF-A2KU	UCEC	TCGA	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1944
p.D197N	TCGA-F4-6856	COAD	TCGA	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1944
p.D197N	DO9114	COAD	ICGC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1944
p.D197N	DO223286	UCEC	ICGC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1944
p.N909I	TCGA-DM-A1D8	COAD	TCGA	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.728
p.N909I	DO8914	COAD	ICGC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.728
p.S250L	TCGA-EE-A20C	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.S250L	TCGA-FR-A726	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.S250L	TCGA-WE-A8K4	SKCM	TCGA	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.S250L	DO222775	MELA	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.S250L	DO48665	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.S250L	DO47665	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.S250L	DO51281	SKCM	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.E515K	TCGA-EE-A2M6	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.E515K	DO222514	MELA	ICGC	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.E515K	DO37976	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.E910K	TCGA-EE-A3AE	SKCM	TCGA	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.591
p.E910K	DO37802	SKCM	ICGC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.591
p.E910K	SIDM00063	Melanoma	GDSC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.591
p.E493K	TCGA-FW-A3R5	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.E493K	DO37406	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.P199S	TCGA-V1-A9Z9	PRAD	TCGA	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.25
p.P199S	DO219395	PRAD	ICGC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.25
p.H254Q	TCGA-XQ-A8TA	PRAD	TCGA	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1667
p.H254Q	DO223662	PRAD	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1667
p.V902A	DO233748	GACA	ICGC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.2222
p.P192T	DO233921	GACA	ICGC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0556
p.H254R	DO20604	KIRC	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1667
p.Y251N	DO220855	MELA	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.25
p.Y251I	DO220855	MELA	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.25
p.D919A	DO220909	MELA	ICGC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.0833
p.D919E	DO220909	MELA	ICGC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.0833
p.P238S	DO222753	MELA	ICGC	VETTS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1667
p.E193K	DO222837	MELA	ICGC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0833
p.N196K	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.N196K	ACH-000789	Lung Cancer	CCLE	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.N196K	NCI-H810	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.N203I	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.6169
p.N203I	ACH-000667	Lung Cancer	CCLE	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.6169
p.N203I	HCC-44	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.6169
p.D913Y	SIDM00942	Oral Cavity Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.25
p.D913Y	ACH-000518	Head and Neck Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.25
p.D913Y	CAL-33	upper aerodigestive tract	COSMIC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.25
p.T505S	SIDM00492	Glioblastoma	GDSC	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.6005
p.T505S	ACH-000269	Brain Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.6005
p.T505S	AM-38	central nervous system	COSMIC	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.6005
p.E908K	SIDM00140	Melanoma	GDSC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.7022
p.E908K	ACH-000968	Skin Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.7022
p.E908K	COLO-792	skin	COSMIC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.7022
p.H212Y	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.H212Y	ACH-000264	Lung Cancer	CCLE	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.H212Y	Calu-6	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.N201I	HCC-44	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.3056
p.D911Y	CAL-33	upper aerodigestive tract	COSMIC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation rewiring degron network	0.3056
p.E906K	COLO-792	skin	COSMIC	NKENE	DEG_APCC_KENBOX_2	906:910	Mutation altering degron motif	0.7022
p.H210Y	Calu-6	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.2222
p.T503S	AM-38	central nervous system	COSMIC	PQSTS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.7116
p.N194K	NCI-H810	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZDBF2

UniProt ID: Q9HCK1

Entrez ID: 57683

Protein name: DBF4-type zinc finger-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZDBF2 in