DegronMD

Uniprot ID: Q9HCK1

Source protein: DBF4-type zinc finger-containing protein 2

Source gene: ZDBF2

Class: DEG_SPOP_SBC_1

Location: 202:206

E3 ligase: SPOP

DEGRON score: 0.6629

ASA_SCORE: 83.56

COIL: 0.8748

CONS_SCORE: 0.6143

DSS_SCORE: 0.6129

HELIX: 0.0542

FCONS_SCORE: 0.8626

RIG_SCORE: 0.6564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V216D	TCGA-49-AARQ	LUAD	TCGA	ANTTS	DEG_SPOP_SBC_1	0.0556
p.V216D	DO51189	LUAD	ICGC	ANTTS	DEG_SPOP_SBC_1	0.0556
p.T205A	TCGA-B5-A3FA	UCEC	TCGA	ANTTS	DEG_SPOP_SBC_1	0.7139
p.T205A	DO52402	UCEC	ICGC	ANTTS	DEG_SPOP_SBC_1	0.7139
p.D214N	TCGA-DA-A1I0	SKCM	TCGA	ANTTS	DEG_SPOP_SBC_1	0.1111
p.D214N	DO37719	SKCM	ICGC	ANTTS	DEG_SPOP_SBC_1	0.1111
p.D197N	TCGA-DF-A2KU	UCEC	TCGA	ANTTS	DEG_SPOP_SBC_1	0.1944
p.D197N	TCGA-F4-6856	COAD	TCGA	ANTTS	DEG_SPOP_SBC_1	0.1944
p.D197N	DO9114	COAD	ICGC	ANTTS	DEG_SPOP_SBC_1	0.1944
p.D197N	DO223286	UCEC	ICGC	ANTTS	DEG_SPOP_SBC_1	0.1944
p.P199S	TCGA-V1-A9Z9	PRAD	TCGA	ANTTS	DEG_SPOP_SBC_1	0.25
p.P199S	DO219395	PRAD	ICGC	ANTTS	DEG_SPOP_SBC_1	0.25
p.P192T	DO233921	GACA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.0556
p.E193K	DO222837	MELA	ICGC	ANTTS	DEG_SPOP_SBC_1	0.0833
p.N196K	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ANTTS	DEG_SPOP_SBC_1	0.1667
p.N196K	ACH-000789	Lung Cancer	CCLE	ANTTS	DEG_SPOP_SBC_1	0.1667
p.N196K	NCI-H810	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	0.1667
p.N203I	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	ANTTS	DEG_SPOP_SBC_1	0.6169
p.N203I	ACH-000667	Lung Cancer	CCLE	ANTTS	DEG_SPOP_SBC_1	0.6169
p.N203I	HCC-44	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	0.6169
p.H212Y	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	ANTTS	DEG_SPOP_SBC_1	0.1667
p.H212Y	ACH-000264	Lung Cancer	CCLE	ANTTS	DEG_SPOP_SBC_1	0.1667
p.H212Y	Calu-6	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	0.1667
p.N201I	HCC-44	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	0.3056
p.H210Y	Calu-6	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	0.2222
p.N194K	NCI-H810	lung	COSMIC	ANTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16070	CD44 antigen	DEG_SPOP_SBC_1	635:639	ANTTS	SPOP	0.7052	More...
P32004	Neural cell adhesion molecule L1	DEG_SPOP_SBC_1	875:879	ANTTS	SPOP	0.8348	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	202:206	ANTTS	SPOP	0.6629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons