DegronMD - P16070(CD44)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T267R	TCGA-29-1783	OV	TCGA	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation altering degron motif	0.7876
p.T267R	DO28222	OV	ICGC	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation altering degron motif	0.7876
p.S391G	TCGA-33-6737	LUSC	TCGA	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.5882
p.S391G	TCGA-33-6737	LUSC	TCGA	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.6993
p.S391G	DO26866	LUSC	ICGC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.5882
p.S391G	DO26866	LUSC	ICGC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.6993
p.Q399E	TCGA-85-8350	LUSC	TCGA	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation rewiring degron network	0.1389
p.Q399E	TCGA-85-8350	LUSC	TCGA	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.1667
p.Q399E	DO45492	LUSC	ICGC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation rewiring degron network	0.1389
p.Q399E	DO45492	LUSC	ICGC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.1667
p.D525Y	TCGA-86-8358	LUAD	TCGA	PTTST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.2778
p.D525Y	DO25471	LUAD	ICGC	PTTST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.2778
p.E522K	TCGA-86-A4JF	LUAD	TCGA	PTTST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1944
p.E522K	DO45317	LUAD	ICGC	PTTST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1944
p.Q263R	TCGA-AZ-4315	COAD	TCGA	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.2778
p.Q263R	DO8842	COAD	ICGC	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.2778
p.H373Y	TCGA-CV-7406	HNSC	TCGA	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1667
p.H373Y	DO15422	HNSC	ICGC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1667
p.E277Q	TCGA-D8-A143	BRCA	TCGA	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1111
p.E277Q	DO1319	BRCA	ICGC	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1111
p.S391R	TCGA-DD-AAC8	LIHC	TCGA	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.6316
p.S391R	TCGA-DD-AAC8	LIHC	TCGA	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.7427
p.S391R	DO52193	LIHC	ICGC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.6316
p.S391R	DO52193	LIHC	ICGC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.7427
p.H370L	TCGA-DD-AACL	LIHC	TCGA	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.0833
p.H370L	DO52208	LIHC	ICGC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.0833
p.D523Y	TCGA-DV-A4VX	KIRC	TCGA	PTTST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.2222
p.D523Y	DO223832	KIRC	ICGC	PTTST	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.2222
p.E401G	TCGA-KN-8430	KICH	TCGA	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation rewiring degron network	0.0833
p.E401G	TCGA-KN-8430	KICH	TCGA	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.1111
p.E401G	DO220500	KICH	ICGC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation rewiring degron network	0.0833
p.E401G	DO220500	KICH	ICGC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.1111
p.Q635H	DO225367	BRCA	ICGC	ANTTS	DEG_SPOP_SBC_1	635:639	Mutation altering degron motif	0.7582
p.E376K	DO233212	GACA	ICGC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation rewiring degron network	0.0833
p.E376K	DO233212	GACA	ICGC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.25
p.G634V	DO228971	LICA	ICGC	ANTTS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.3056
p.S391I	DO229038	LICA	ICGC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.623
p.S391I	DO229038	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.7341
p.S391I	DO229006	LICA	ICGC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.623
p.S391I	DO229006	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.7341
p.R632S	DO229041	LICA	ICGC	ANTTS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.25
p.D278Y	DO45316	LUAD	ICGC	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.0833
p.P265H	DO35442	PACA	ICGC	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation altering degron motif	0.7694
p.T256M	DO47789	STAD	ICGC	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.0833
p.G629V	SIDM00928	Breast Carcinoma	GDSC	ANTTS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1667
p.G629V	CAL-85-1	breast	COSMIC	ANTTS	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1667
p.H372R	SIDM00292	Small Cell Lung Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1389
p.H372R	ACH-002077	Lung Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1389
p.H372R	LU-165	lung	COSMIC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1389
p.S390T	SIDM01019	Acute Myeloid Leukemia	GDSC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.6005
p.S390T	SIDM01019	Acute Myeloid Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.6005
p.S390T	ACH-002258	Leukemia	CCLE	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.6005
p.S390T	ACH-002258	Leukemia	CCLE	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.6005
p.S390T	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.6005
p.S390T	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.6005
p.P379A	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation altering degron motif	0.6392
p.P379A	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation altering degron motif	0.6392
p.P379A	SIDM00503	Gastric Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation altering degron motif	0.6392
p.P379A	KYSE-520	oesophagus	COSMIC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation altering degron motif	0.6392
p.P379A	KYSE-450	oesophagus	COSMIC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation altering degron motif	0.6392
p.P379A	FU97	stomach	COSMIC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation altering degron motif	0.6392
p.R270Q	ES5	bone	COSMIC	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.3056
p.M396R	SNU-475	liver	COSMIC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation rewiring degron network	0.2222
p.M396R	SNU-475	liver	COSMIC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.25
p.A390T	MFE-296	endometrium	COSMIC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.7139
p.A390T	MFE-296	endometrium	COSMIC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.7139
p.M394V	OPM-2	haematopoietic and lymphoid tissue	COSMIC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation rewiring degron network	0.2778
p.M394V	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation rewiring degron network	0.3056
p.G380V	CAL-85-1	breast	COSMIC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation altering degron motif	0.7532
p.S391N	CAL-51	breast	COSMIC	IQATPSST	DEG_SCF_FBW7_1	385:392	Mutation altering degron motif	0.5958
p.S391N	CAL-51	breast	COSMIC	PSSTT	DEG_SPOP_SBC_1	389:393	Mutation altering degron motif	0.7069
p.S259C	TGBC11TKB	stomach	COSMIC	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1667
p.D273E	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.2222
p.R370P	JHOS-2	ovary	COSMIC	PHSTS	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.0833

Kaplan plot for CD44 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD44

UniProt ID: P16070

Entrez ID: 960

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD44 in