DegronMD

Uniprot ID: P16070

Source protein: CD44 antigen

Source gene: CD44

Class: DEG_SPOP_SBC_1

Location: 379:383

E3 ligase: SPOP

DEGRON score: 0.8054

ASA_SCORE: 91.26

COIL: 0.9158

CONS_SCORE: 0.4472

DSS_SCORE: 0.8671

HELIX: 0.041

FCONS_SCORE: 1.0596

RIG_SCORE: 0.5881

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H373Y	TCGA-CV-7406	HNSC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1667
p.H373Y	DO15422	HNSC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1667
p.H370L	TCGA-DD-AACL	LIHC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.0833
p.H370L	DO52208	LIHC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.0833
p.E376K	DO233212	GACA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.25
p.H372R	SIDM00292	Small Cell Lung Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.1389
p.H372R	ACH-002077	Lung Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	0.1389
p.H372R	LU-165	lung	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.1389
p.P379A	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.6392
p.P379A	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.6392
p.P379A	SIDM00503	Gastric Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.6392
p.P379A	KYSE-520	oesophagus	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.6392
p.P379A	KYSE-450	oesophagus	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.6392
p.P379A	FU97	stomach	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.6392
p.G380V	CAL-85-1	breast	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.7532
p.R370P	JHOS-2	ovary	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2975:2979	PHSTS	SPOP	0.9883	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	379:383	PHSTS	SPOP	0.8054	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	874:878	PHSTS	SPOP	0.9468	More...
Q8HWS3	DNA-binding protein RFX6	DEG_SPOP_SBC_1	711:715	PHSTS	SPOP	0.9944	More...
Q8NG27	E3 ubiquitin-protein ligase Praja-1	DEG_SPOP_SBC_1	284:288	PHSTS	SPOP	0.7228	More...
Q9P2P5	E3 ubiquitin-protein ligase HECW2	DEG_SPOP_SBC_1	905:909	PHSTS	SPOP	0.9068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons