DegronMD

Uniprot ID: Q9P2P5

Source protein: E3 ubiquitin-protein ligase HECW2

Source gene: HECW2

Class: DEG_SPOP_SBC_1

Location: 905:909

E3 ligase: SPOP

DEGRON score: 0.9068

ASA_SCORE: 97.92

COIL: 0.9254

CONS_SCORE: 0.3452

DSS_SCORE: 0.3149

HELIX: 0.053

FCONS_SCORE: 0.9852

RIG_SCORE: 0.7167

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T914M	TCGA-55-8506	LUAD	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1944
p.T914M	DO45390	LUAD	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.T914M	SIDM00499	Prostate Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.T914M	22RV1	prostate	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.R900Q	TCGA-77-7463	LUSC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1944
p.R900Q	DO26716	LUSC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.R900Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.R900Q	SIDM01622	Breast Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.R900Q	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.A896T	TCGA-77-A5GF	LUSC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.0833
p.A896T	DO50101	LUSC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.0833
p.L916M	TCGA-A5-A0G2	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1389
p.L916M	DO41235	UCEC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1389
p.R899Q	TCGA-EE-A29M	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1667
p.R899Q	DO37404	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1667
p.R900L	TCGA-EE-A2GT	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1944
p.R900L	TCGA-FS-A1ZQ	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1944
p.R900L	DO37442	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.R900L	DO37946	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.S909F	TCGA-XF-A9ST	BLCA	TCGA	PHSTS	DEG_SPOP_SBC_1	0.9093
p.S909F	DO223599	BLCA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.9093
p.A896E	DO228948	LICA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.0833
p.E901D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PHSTS	DEG_SPOP_SBC_1	0.2222
p.E901D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.2222
p.L915F	SIDM00561	Other Blood Cancers	GDSC	PHSTS	DEG_SPOP_SBC_1	0.1667
p.L915F	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.1667
p.L917H	ACH-000182	Bile Duct Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	0.1111
p.E908D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.6758
p.R907Q	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2975:2979	PHSTS	SPOP	0.9883	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	379:383	PHSTS	SPOP	0.8054	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	874:878	PHSTS	SPOP	0.9468	More...
Q8HWS3	DNA-binding protein RFX6	DEG_SPOP_SBC_1	711:715	PHSTS	SPOP	0.9944	More...
Q8NG27	E3 ubiquitin-protein ligase Praja-1	DEG_SPOP_SBC_1	284:288	PHSTS	SPOP	0.7228	More...
Q9P2P5	E3 ubiquitin-protein ligase HECW2	DEG_SPOP_SBC_1	905:909	PHSTS	SPOP	0.9068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PHSTS

Degron related mutations and impact score

Drug responses associated with HECW2 mutations

All proteins holding degron of PHSTS