DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SPOP_SBC_1

Location: 2975:2979

E3 ligase: SPOP

DEGRON score: 0.9883

ASA_SCORE: 82.16

COIL: 0.7816

CONS_SCORE: 0.5076

DSS_SCORE: 0.5005

HELIX: 0.02

FCONS_SCORE: 1.1538

RIG_SCORE: 0.7293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2970V	TCGA-56-7823	LUSC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1944
p.G2970V	DO223721	LUSC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.A2980S	TCGA-AG-A00Y	READ	TCGA	PHSTS	DEG_SPOP_SBC_1	0.3056
p.A2980S	DO36542	READ	ICGC	PHSTS	DEG_SPOP_SBC_1	0.3056
p.A2980D	TCGA-AG-A00Y	READ	TCGA	PHSTS	DEG_SPOP_SBC_1	0.3056
p.A2980D	DO36542	READ	ICGC	PHSTS	DEG_SPOP_SBC_1	0.3056
p.V2986I	TCGA-E6-A1LX	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1389
p.V2986I	DO41020	UCEC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1389
p.E2965K	TCGA-EE-A29M	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.0556
p.E2965K	DO37404	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.0556
p.S2977Y	TCGA-EE-A2GT	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.712
p.S2977Y	DO37946	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.712
p.A2971T	DO222570	ESCA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.2222
p.G2970D	DO50970	LICA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.T2983I	DO220878	MELA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.2222
p.Q2973H	SIDM00155	Head and Neck Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.2778
p.Q2973H	PCI-38	upper_aerodigestive_tract	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.2778
p.G2970S	SIDM00045	Gastric Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.G2970S	ACH-002141	Gastric Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	0.1944
p.G2970S	HSC-39	stomach	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2975:2979	PHSTS	SPOP	0.9883	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	379:383	PHSTS	SPOP	0.8054	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	874:878	PHSTS	SPOP	0.9468	More...
Q8HWS3	DNA-binding protein RFX6	DEG_SPOP_SBC_1	711:715	PHSTS	SPOP	0.9944	More...
Q8NG27	E3 ubiquitin-protein ligase Praja-1	DEG_SPOP_SBC_1	284:288	PHSTS	SPOP	0.7228	More...
Q9P2P5	E3 ubiquitin-protein ligase HECW2	DEG_SPOP_SBC_1	905:909	PHSTS	SPOP	0.9068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons