DegronMD

Uniprot ID: Q8NG27

Source protein: E3 ubiquitin-protein ligase Praja-1

Source gene: PJA1

Class: DEG_SPOP_SBC_1

Location: 284:288

E3 ligase: SPOP

DEGRON score: 0.7228

ASA_SCORE: 70.96

COIL: 0.7208

CONS_SCORE: 0.2581

DSS_SCORE: 0.6137

HELIX: 0.2104

FCONS_SCORE: 0.9117

RIG_SCORE: 0.6781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H285R	TCGA-06-5416	GBM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.7133
p.D281N	TCGA-AX-A1CE	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.25
p.M283V	TCGA-CD-A4MG	STAD	TCGA	PHSTS	DEG_SPOP_SBC_1	0.3056
p.D281E	TCGA-DF-A2KU	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.25
p.W290L	TCGA-EE-A2A5	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.2778
p.D282N	TCGA-FI-A2D5	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.2778
p.H285L	TCGA-KL-8326	KICH	TCGA	PHSTS	DEG_SPOP_SBC_1	0.6202
p.R288C	DO51863	BLCA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.8301
p.R288H	DO51634	CESC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.8244
p.R288H	DO8224	COAD	ICGC	PHSTS	DEG_SPOP_SBC_1	0.8244
p.T297M	DO233941	GACA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.0833
p.T297M	DO41638	UCEC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.0833
p.R288L	DO50917	LICA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.8428
p.M290L	DO24307	LUAD	ICGC	PHSTS	DEG_SPOP_SBC_1	0.2778
p.P284S	DO23818	LUAD	ICGC	PHSTS	DEG_SPOP_SBC_1	0.6752
p.R287Q	DO47282	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.7329
p.P284L	DO42568	UCEC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.7582
p.D279V	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.D279V	ACH-000656	Lymphoma	CCLE	PHSTS	DEG_SPOP_SBC_1	0.1944
p.D279V	SU-DHL-8	NS	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.S286N	SIDM01126	Small Cell Lung Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.7069
p.S286N	ACH-001599	Lung Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	0.7069
p.S286N	NCI-H64	lung	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.7069
p.D281A	SIDM01100	Neuroblastoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.25
p.D281A	ACH-000366	Neuroblastoma	CCLE	PHSTS	DEG_SPOP_SBC_1	0.25
p.D281A	SK-N-DZ	autonomic_ganglia	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.25
p.P298H	LU-139	lung	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.0556
p.P293H	SNU-182	liver	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2975:2979	PHSTS	SPOP	0.9883	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	379:383	PHSTS	SPOP	0.8054	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	874:878	PHSTS	SPOP	0.9468	More...
Q8HWS3	DNA-binding protein RFX6	DEG_SPOP_SBC_1	711:715	PHSTS	SPOP	0.9944	More...
Q8NG27	E3 ubiquitin-protein ligase Praja-1	DEG_SPOP_SBC_1	284:288	PHSTS	SPOP	0.7228	More...
Q9P2P5	E3 ubiquitin-protein ligase HECW2	DEG_SPOP_SBC_1	905:909	PHSTS	SPOP	0.9068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PHSTS

Degron related mutations and impact score

Drug responses associated with PJA1 mutations

All proteins holding degron of PHSTS