DegronMD - Q8NG27(PJA1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H285R	TCGA-06-5416	GBM	TCGA	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7133
p.K270N	TCGA-A5-A0G1	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.6918
p.K270N	DO14662	HNSC	ICGC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.6918
p.A106D	TCGA-A5-A0G1	UCEC	TCGA	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.1667
p.I273F	TCGA-A5-A2K5	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.7415
p.I273F	TCGA-AP-A1DV	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.7415
p.I273F	TCGA-DF-A2KN	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.7415
p.S107L	TCGA-A5-A2K5	UCEC	TCGA	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.1389
p.S107L	TCGA-AG-A002	READ	TCGA	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.1389
p.S107L	TCGA-DK-A3IL	BLCA	TCGA	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.1389
p.S85L	TCGA-AP-A056	UCEC	TCGA	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.S85L	TCGA-AP-A056	UCEC	TCGA	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.1944
p.S85L	TCGA-BH-A0HA	BRCA	TCGA	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.S85L	TCGA-BH-A0HA	BRCA	TCGA	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.1944
p.D281N	TCGA-AX-A1CE	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.D281N	TCGA-AX-A1CE	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.1944
p.N267H	TCGA-B5-A11N	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.25
p.E94K	TCGA-BH-A0DZ	BRCA	TCGA	NIDNEDYSRYP	CBL_PTK	90:100	Mutation altering degron motif	0.591
p.M283V	TCGA-CD-A4MG	STAD	TCGA	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.3056
p.M283V	TCGA-CD-A4MG	STAD	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.1389
p.R76C	TCGA-D3-A51T	SKCM	TCGA	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.D281E	TCGA-DF-A2KU	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.D281E	TCGA-DF-A2KU	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.1944
p.S73A	TCGA-DS-A1OC	CESC	TCGA	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.7588
p.R77C	TCGA-E6-A1LX	UCEC	TCGA	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.W290L	TCGA-EE-A2A5	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2778
p.D282N	TCGA-FI-A2D5	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2778
p.D282N	TCGA-FI-A2D5	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.1667
p.H285L	TCGA-KL-8326	KICH	TCGA	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.6202
p.Q63E	TCGA-S5-A6DX	BLCA	TCGA	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.Q63E	SIDM00652	Small Cell Lung Carcinoma	GDSC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.Q63E	NCI-H1105	lung	COSMIC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.I273L	TCGA-VS-A9V4	CESC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.6063
p.W79R	TCGA-YR-A95A	CHOL	TCGA	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2222
p.R288C	DO51863	BLCA	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.8301
p.E74K	DO5465	BRCA	ICGC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.7022
p.R288H	DO51634	CESC	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.8244
p.R288H	DO8224	COAD	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.8244
p.A103T	DO223732	CESC	ICGC	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.25
p.T297M	DO233941	GACA	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833
p.T297M	DO41638	UCEC	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833
p.L106V	DO48676	KIRC	ICGC	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.1667
p.D98E	DO229038	LICA	ICGC	NIDNEDYSRYP	CBL_PTK	90:100	Mutation altering degron motif	0.6758
p.R288L	DO50917	LICA	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.8428
p.M290L	DO24307	LUAD	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2778
p.G61V	DO25058	LUAD	ICGC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.G61V	DO38195	STAD	ICGC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0556
p.P284S	DO23818	LUAD	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.6752
p.K95N	DO26200	LUAD	ICGC	NIDNEDYSRYP	CBL_PTK	90:100	Mutation altering degron motif	0.6918
p.K90M	DO26798	LUSC	ICGC	NIDNEDYSRYP	CBL_PTK	90:100	Mutation altering degron motif	0.8062
p.D69N	DO232834	PBCA	ICGC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.E74G	DO218842	SKCA	ICGC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.7199
p.R287Q	DO47282	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7329
p.E263K	DO37823	SKCM	ICGC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.1389
p.E73K	DO51301	SKCM	ICGC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.7022
p.P78H	DO219773	UCEC	ICGC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation blocking phosphorylation signal	0.6944
p.P284L	DO42568	UCEC	ICGC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7582
p.P82L	DO41127	UCEC	ICGC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1389
p.P82L	DO41127	UCEC	ICGC	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.1111
p.T88N	DO42472	UCEC	ICGC	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.2778
p.R110I	SIDM02015	Colorectal Carcinoma	GDSC	NIDNEDYSRYP	CBL_PTK	90:100	Mutation rewiring degron network	0.0556
p.I273N	SIDM00216	Colorectal Carcinoma	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.728
p.I273N	SIDM00837	Colorectal Carcinoma	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.728
p.I273N	ACH-000958	Colon/Colorectal Cancer	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.728
p.I273N	ACH-000989	Colon/Colorectal Cancer	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.728
p.I273N	SW48	large intestine	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.728
p.I273N	SNU-175	large intestine	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.728
p.D279V	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.D279V	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.25
p.D279V	ACH-000656	Lymphoma	CCLE	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.D279V	ACH-000656	Lymphoma	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.25
p.D279V	SU-DHL-8	NS	COSMIC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.D279V	SU-DHL-8	NS	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.25
p.S286N	SIDM01126	Small Cell Lung Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7069
p.S286N	ACH-001599	Lung Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7069
p.S286N	NCI-H64	lung	COSMIC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7069
p.P271A	SIDM01154	T-Lymphoblastic Leukemia	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.6392
p.P271A	ACH-000953	Leukemia	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.6392
p.P271A	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation altering degron motif	0.6392
p.D281A	SIDM01100	Neuroblastoma	GDSC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.D281A	SIDM01100	Neuroblastoma	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.1944
p.D281A	ACH-000366	Neuroblastoma	CCLE	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.D281A	ACH-000366	Neuroblastoma	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.1944
p.D281A	SK-N-DZ	autonomic ganglia	COSMIC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.D281A	SK-N-DZ	autonomic ganglia	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	270:276	Mutation rewiring degron network	0.1944
p.R77H	SIDM01133	Other Solid Cancers	GDSC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.R77H	ACH-002177	Lung Cancer	CCLE	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.R77H	NCI-H835	lung	COSMIC	PFSTT	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.P298H	LU-139	lung	COSMIC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0556
p.P293H	SNU-182	liver	COSMIC	PHSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PJA1

UniProt ID: Q8NG27

Entrez ID: 64219

Protein name: E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PJA1 in