DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NIDNEDYSRYP
Uniprot ID:
Q8NG27
Source protein:
E3 ubiquitin-protein ligase Praja-1
Source gene:
PJA1
Class:
CBL_PTK
Location:
90:100
E3 ligase:
CBL
DEGRON score:
0.9185
ASA_SCORE:
74.2
COIL:
0.6724
CONS_SCORE:
0.2385
DSS_SCORE:
0.5567
HELIX:
0.223
FCONS_SCORE:
0.8002
RIG_SCORE:
0.7341
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A106D
TCGA-A5-A0G1
UCEC
TCGA
NIDNEDYSRYP
CBL_PTK
0.1667
p.S107L
TCGA-A5-A2K5
UCEC
TCGA
NIDNEDYSRYP
CBL_PTK
0.1389
p.S107L
TCGA-AG-A002
READ
TCGA
NIDNEDYSRYP
CBL_PTK
0.1389
p.S107L
TCGA-DK-A3IL
BLCA
TCGA
NIDNEDYSRYP
CBL_PTK
0.1389
p.S85L
TCGA-AP-A056
UCEC
TCGA
NIDNEDYSRYP
CBL_PTK
0.1944
p.S85L
TCGA-BH-A0HA
BRCA
TCGA
NIDNEDYSRYP
CBL_PTK
0.1944
p.E94K
TCGA-BH-A0DZ
BRCA
TCGA
NIDNEDYSRYP
CBL_PTK
0.591
p.A103T
DO223732
CESC
ICGC
NIDNEDYSRYP
CBL_PTK
0.25
p.L106V
DO48676
KIRC
ICGC
NIDNEDYSRYP
CBL_PTK
0.1667
p.D98E
DO229038
LICA
ICGC
NIDNEDYSRYP
CBL_PTK
0.6758
p.K95N
DO26200
LUAD
ICGC
NIDNEDYSRYP
CBL_PTK
0.6918
p.K90M
DO26798
LUSC
ICGC
NIDNEDYSRYP
CBL_PTK
0.8062
p.P82L
DO41127
UCEC
ICGC
NIDNEDYSRYP
CBL_PTK
0.1111
p.T88N
DO42472
UCEC
ICGC
NIDNEDYSRYP
CBL_PTK
0.2778
p.R110I
SIDM02015
Colorectal Carcinoma
GDSC
NIDNEDYSRYP
CBL_PTK
0.0556
Drug responses associated with PJA1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NIDNEDYSRYP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NG27
E3 ubiquitin-protein ligase Praja-1
CBL_PTK
90:100
NIDNEDYSRYP
CBL
0.9185
More...
