DegronMD

Uniprot ID: Q8NG27

Source protein: E3 ubiquitin-protein ligase Praja-1

Source gene: PJA1

Class: DEG_SPOP_SBC_1

Location: 71:75

E3 ligase: SPOP

DEGRON score: 0.8783

ASA_SCORE: 66.94

COIL: 0.6836

CONS_SCORE: 0.2661

DSS_SCORE: 0.6168

HELIX: 0.0572

FCONS_SCORE: 0.9159

RIG_SCORE: 0.6224

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S73A	TCGA-DS-A1OC	CESC	TCGA	PFSTT	DEG_SPOP_SBC_1	0.7588
p.E74G	DO218842	SKCA	ICGC	PFSTT	DEG_SPOP_SBC_1	0.7199
p.E74K	DO5465	BRCA	ICGC	PFSTT	DEG_SPOP_SBC_1	0.7022
p.E73K	DO51301	SKCM	ICGC	PFSTT	DEG_SPOP_SBC_1	0.7022
p.P78H	DO219773	UCEC	ICGC	PFSTT	DEG_SPOP_SBC_1	0.6944
p.R76C	TCGA-D3-A51T	SKCM	TCGA	PFSTT	DEG_SPOP_SBC_1	0.3056
p.R77C	TCGA-E6-A1LX	UCEC	TCGA	PFSTT	DEG_SPOP_SBC_1	0.2778
p.D69N	DO232834	PBCA	ICGC	PFSTT	DEG_SPOP_SBC_1	0.2778
p.R77H	SIDM01133	Other Solid Cancers	GDSC	PFSTT	DEG_SPOP_SBC_1	0.2778
p.R77H	ACH-002177	Lung Cancer	CCLE	PFSTT	DEG_SPOP_SBC_1	0.2778
p.R77H	NCI-H835	lung	COSMIC	PFSTT	DEG_SPOP_SBC_1	0.2778
p.W79R	TCGA-YR-A95A	CHOL	TCGA	PFSTT	DEG_SPOP_SBC_1	0.2222
p.P82L	DO41127	UCEC	ICGC	PFSTT	DEG_SPOP_SBC_1	0.1389
p.Q63E	TCGA-S5-A6DX	BLCA	TCGA	PFSTT	DEG_SPOP_SBC_1	0.1111
p.Q63E	SIDM00652	Small Cell Lung Carcinoma	GDSC	PFSTT	DEG_SPOP_SBC_1	0.1111
p.Q63E	NCI-H1105	lung	COSMIC	PFSTT	DEG_SPOP_SBC_1	0.1111
p.S85L	TCGA-AP-A056	UCEC	TCGA	PFSTT	DEG_SPOP_SBC_1	0.0556
p.S85L	TCGA-BH-A0HA	BRCA	TCGA	PFSTT	DEG_SPOP_SBC_1	0.0556
p.G61V	DO25058	LUAD	ICGC	PFSTT	DEG_SPOP_SBC_1	0.0556
p.G61V	DO38195	STAD	ICGC	PFSTT	DEG_SPOP_SBC_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG27	E3 ubiquitin-protein ligase Praja-1	DEG_SPOP_SBC_1	71:75	PFSTT	SPOP	0.8783	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons