DegronMD

Uniprot ID: Q8NG27

Source protein: E3 ubiquitin-protein ligase Praja-1

Source gene: PJA1

Class: LIG_APCC_ABBAyCdc20_2

Location: 270:276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.998

ASA_SCORE: 96.3286

COIL: 0.8139

CONS_SCORE: 0.3458

DSS_SCORE: 0.4898

HELIX: 0.1463

FCONS_SCORE: 1.3849

RIG_SCORE: 0.8011

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K270N	TCGA-A5-A0G1	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.6918
p.K270N	DO14662	HNSC	ICGC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.6918
p.I273F	TCGA-A5-A2K5	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.7415
p.I273F	TCGA-AP-A1DV	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.7415
p.I273F	TCGA-DF-A2KN	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.7415
p.D281N	TCGA-AX-A1CE	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N267H	TCGA-B5-A11N	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.25
p.M283V	TCGA-CD-A4MG	STAD	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D281E	TCGA-DF-A2KU	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D282N	TCGA-FI-A2D5	UCEC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.I273L	TCGA-VS-A9V4	CESC	TCGA	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.6063
p.E263K	DO37823	SKCM	ICGC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.I273N	SIDM00216	Colorectal Carcinoma	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.728
p.I273N	SIDM00837	Colorectal Carcinoma	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.728
p.I273N	ACH-000958	Colon/Colorectal Cancer	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.728
p.I273N	ACH-000989	Colon/Colorectal Cancer	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.728
p.I273N	SW48	large_intestine	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.728
p.I273N	SNU-175	large_intestine	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.728
p.D279V	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.25
p.D279V	ACH-000656	Lymphoma	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.25
p.D279V	SU-DHL-8	NS	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.25
p.P271A	SIDM01154	T-Lymphoblastic Leukemia	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.6392
p.P271A	ACH-000953	Leukemia	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.6392
p.P271A	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.6392
p.D281A	SIDM01100	Neuroblastoma	GDSC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D281A	ACH-000366	Neuroblastoma	CCLE	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D281A	SK-N-DZ	autonomic_ganglia	COSMIC	KPKIFFD	LIG_APCC_ABBAyCdc20_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KPKIFFD

Degron related mutations and impact score

Drug responses associated with PJA1 mutations

All proteins holding degron of KPKIFFD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG27	E3 ubiquitin-protein ligase Praja-1	LIG_APCC_ABBAyCdc20_2	270:276	KPKIFFD	APC,CDC20,FZR1	0.998	More...