DegronMD - Q9P2P5(HECW2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A33T	TCGA-05-5420	LUAD	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.1111
p.A33T	DO26005	LUAD	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.1111
p.Q29L	TCGA-55-1592	LUAD	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2222
p.Q29L	DO23556	LUAD	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2222
p.T914M	TCGA-55-8506	LUAD	TCGA	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.T914M	DO45390	LUAD	ICGC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.T914M	SIDM00499	Prostate Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.T914M	22RV1	prostate	COSMIC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.R900Q	TCGA-77-7463	LUSC	TCGA	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.R900Q	DO26716	LUSC	ICGC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.R900Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.R900Q	SIDM01622	Breast Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.R900Q	REH	haematopoietic and lymphoid tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.A896T	TCGA-77-A5GF	LUSC	TCGA	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.0833
p.A896T	DO50101	LUSC	ICGC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.0833
p.L916M	TCGA-A5-A0G2	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1389
p.L916M	DO41235	UCEC	ICGC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1389
p.R15Q	TCGA-AA-A00N	COAD	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.2778
p.R15Q	TCGA-AA-A00N	COAD	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.R15Q	TCGA-D3-A2J8	SKCM	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.2778
p.R15Q	TCGA-D3-A2J8	SKCM	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.R15Q	TCGA-XK-AAJ3	PRAD	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.2778
p.R15Q	TCGA-XK-AAJ3	PRAD	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.R15Q	DO228471	BRCA	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.2778
p.R15Q	DO228471	BRCA	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.R15Q	DO9876	COAD	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.2778
p.R15Q	DO9876	COAD	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.R15Q	DO51408	PRAD	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.2778
p.R15Q	DO51408	PRAD	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.R15Q	DO37778	SKCM	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.2778
p.R15Q	DO37778	SKCM	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.E26K	TCGA-AC-A23H	BRCA	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.E26K	DO2401	BRCA	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.R14H	TCGA-AG-3731	READ	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.R14H	TCGA-AG-3731	READ	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2778
p.R14H	TCGA-CG-5721	STAD	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.R14H	TCGA-CG-5721	STAD	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2778
p.R14H	DO233731	GACA	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.R14H	DO233731	GACA	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2778
p.R14H	DO36463	READ	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.R14H	DO36463	READ	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2778
p.R14H	DO38192	STAD	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.R14H	DO38192	STAD	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2778
p.R20Q	TCGA-AR-A256	BRCA	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6218
p.R20Q	DO4155	BRCA	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6218
p.R20Q	SIDM00217	Colorectal Carcinoma	GDSC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6218
p.R20Q	ACH-000999	Colon/Colorectal Cancer	CCLE	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6218
p.R20Q	SNU-1040	large intestine	COSMIC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6218
p.R14C	TCGA-AX-A1CE	UCEC	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.R14C	TCGA-AX-A1CE	UCEC	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2778
p.R14C	DO42280	UCEC	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.R14C	DO42280	UCEC	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2778
p.R14C	SIDM02059	Colorectal Carcinoma	GDSC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.R14C	SIDM02059	Colorectal Carcinoma	GDSC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.2778
p.P17L	TCGA-D3-A8GM	SKCM	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6471
p.P17L	DO50288	SKCM	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6471
p.P17S	TCGA-E8-A2JQ	THCA	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.5641
p.P17S	DO39511	THCA	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.5641
p.R899Q	TCGA-EE-A29M	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1667
p.R899Q	DO37404	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1667
p.N16D	TCGA-EE-A2A2	SKCM	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.5821
p.N16D	DO37583	SKCM	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.5821
p.R900L	TCGA-EE-A2GT	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.R900L	TCGA-FS-A1ZQ	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.R900L	DO37442	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.R900L	DO37946	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1944
p.S4L	TCGA-EE-A3AH	SKCM	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.75
p.S4L	TCGA-FR-A729	SKCM	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.75
p.S4L	DO222635	MELA	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.75
p.S4L	DO37443	SKCM	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.75
p.S4L	DO48618	SKCM	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.75
p.V12A	TCGA-FF-8041	DLBC	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.6936
p.V12A	DO222305	DLBC	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.6936
p.Y21N	TCGA-FS-A4F9	SKCM	TCGA	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.7059
p.Y21N	DO38069	SKCM	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.7059
p.S909F	TCGA-XF-A9ST	BLCA	TCGA	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation altering degron motif	0.9093
p.S909F	DO223599	BLCA	ICGC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation altering degron motif	0.9093
p.A2D	DO50406	ESAD	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.6944
p.A896E	DO228948	LICA	ICGC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.0833
p.S24I	DO45231	LIRI	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.7341
p.E7K	DO222420	MELA	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.591
p.L28F	DO222904	MELA	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.25
p.P25S	DO232224	PBCA	ICGC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6752
p.E901D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.2222
p.E901D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.2222
p.L915F	SIDM00561	Other Blood Cancers	GDSC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1667
p.L915F	MLMA	haematopoietic and lymphoid tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1667
p.R20W	SIDM00980	Gastric Carcinoma	GDSC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.7523
p.R20W	ACH-000948	Gastric Cancer	CCLE	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.7523
p.R20W	23132-87	stomach	COSMIC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.7523
p.L917H	ACH-000182	Bile Duct Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation rewiring degron network	0.1111
p.G24E	ACH-000835	Sarcoma	CCLE	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.7199
p.G24E	GCT	soft tissue	COSMIC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.7199
p.G3W	ACH-000975	Lung Cancer	CCLE	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.7222
p.E18D	ACH-000997	Colon/Colorectal Cancer	CCLE	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6758
p.E18D	HCT-15	large intestine	COSMIC	NPQMRYTLSP	CBL_PTK	16:25	Mutation altering degron motif	0.6758
p.R15P	ACH-001061	Colon/Colorectal Cancer	CCLE	AREHLLFVR	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.2778
p.R15P	ACH-001061	Colon/Colorectal Cancer	CCLE	NPQMRYTLSP	CBL_PTK	16:25	Mutation rewiring degron network	0.3056
p.E908D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation altering degron motif	0.6758
p.R907Q	REH	haematopoietic and lymphoid tissue	COSMIC	PHSTS	DEG_SPOP_SBC_1	905:909	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HECW2

UniProt ID: Q9P2P5

Entrez ID: 57520

Protein name: E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HECW2 in