DegronMD

Uniprot ID: Q9P2P5

Source protein: E3 ubiquitin-protein ligase HECW2

Source gene: HECW2

Class: CBL_PTK

Location: 16:25

E3 ligase: CBL

DEGRON score: 0.9966

ASA_SCORE: 73.4

COIL: 0.7549

CONS_SCORE: 0.3452

DSS_SCORE: 0.4678

HELIX: 0.1395

FCONS_SCORE: 1.0072

RIG_SCORE: 0.7198

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A33T	TCGA-05-5420	LUAD	TCGA	NPQMRYTLSP	CBL_PTK	0.1111
p.A33T	DO26005	LUAD	ICGC	NPQMRYTLSP	CBL_PTK	0.1111
p.Q29L	TCGA-55-1592	LUAD	TCGA	NPQMRYTLSP	CBL_PTK	0.2222
p.Q29L	DO23556	LUAD	ICGC	NPQMRYTLSP	CBL_PTK	0.2222
p.R15Q	TCGA-AA-A00N	COAD	TCGA	NPQMRYTLSP	CBL_PTK	0.3056
p.R15Q	TCGA-D3-A2J8	SKCM	TCGA	NPQMRYTLSP	CBL_PTK	0.3056
p.R15Q	TCGA-XK-AAJ3	PRAD	TCGA	NPQMRYTLSP	CBL_PTK	0.3056
p.R15Q	DO228471	BRCA	ICGC	NPQMRYTLSP	CBL_PTK	0.3056
p.R15Q	DO9876	COAD	ICGC	NPQMRYTLSP	CBL_PTK	0.3056
p.R15Q	DO51408	PRAD	ICGC	NPQMRYTLSP	CBL_PTK	0.3056
p.R15Q	DO37778	SKCM	ICGC	NPQMRYTLSP	CBL_PTK	0.3056
p.E26K	TCGA-AC-A23H	BRCA	TCGA	NPQMRYTLSP	CBL_PTK	0.3056
p.E26K	DO2401	BRCA	ICGC	NPQMRYTLSP	CBL_PTK	0.3056
p.R14H	TCGA-AG-3731	READ	TCGA	NPQMRYTLSP	CBL_PTK	0.2778
p.R14H	TCGA-CG-5721	STAD	TCGA	NPQMRYTLSP	CBL_PTK	0.2778
p.R14H	DO233731	GACA	ICGC	NPQMRYTLSP	CBL_PTK	0.2778
p.R14H	DO36463	READ	ICGC	NPQMRYTLSP	CBL_PTK	0.2778
p.R14H	DO38192	STAD	ICGC	NPQMRYTLSP	CBL_PTK	0.2778
p.R20Q	TCGA-AR-A256	BRCA	TCGA	NPQMRYTLSP	CBL_PTK	0.6218
p.R20Q	DO4155	BRCA	ICGC	NPQMRYTLSP	CBL_PTK	0.6218
p.R20Q	SIDM00217	Colorectal Carcinoma	GDSC	NPQMRYTLSP	CBL_PTK	0.6218
p.R20Q	ACH-000999	Colon/Colorectal Cancer	CCLE	NPQMRYTLSP	CBL_PTK	0.6218
p.R20Q	SNU-1040	large_intestine	COSMIC	NPQMRYTLSP	CBL_PTK	0.6218
p.R14C	TCGA-AX-A1CE	UCEC	TCGA	NPQMRYTLSP	CBL_PTK	0.2778
p.R14C	DO42280	UCEC	ICGC	NPQMRYTLSP	CBL_PTK	0.2778
p.R14C	SIDM02059	Colorectal Carcinoma	GDSC	NPQMRYTLSP	CBL_PTK	0.2778
p.P17L	TCGA-D3-A8GM	SKCM	TCGA	NPQMRYTLSP	CBL_PTK	0.6471
p.P17L	DO50288	SKCM	ICGC	NPQMRYTLSP	CBL_PTK	0.6471
p.P17S	TCGA-E8-A2JQ	THCA	TCGA	NPQMRYTLSP	CBL_PTK	0.5641
p.P17S	DO39511	THCA	ICGC	NPQMRYTLSP	CBL_PTK	0.5641
p.N16D	TCGA-EE-A2A2	SKCM	TCGA	NPQMRYTLSP	CBL_PTK	0.5821
p.N16D	DO37583	SKCM	ICGC	NPQMRYTLSP	CBL_PTK	0.5821
p.Y21N	TCGA-FS-A4F9	SKCM	TCGA	NPQMRYTLSP	CBL_PTK	0.7059
p.Y21N	DO38069	SKCM	ICGC	NPQMRYTLSP	CBL_PTK	0.7059
p.S24I	DO45231	LIRI	ICGC	NPQMRYTLSP	CBL_PTK	0.7341
p.L28F	DO222904	MELA	ICGC	NPQMRYTLSP	CBL_PTK	0.25
p.P25S	DO232224	PBCA	ICGC	NPQMRYTLSP	CBL_PTK	0.6752
p.R20W	SIDM00980	Gastric Carcinoma	GDSC	NPQMRYTLSP	CBL_PTK	0.7523
p.R20W	ACH-000948	Gastric Cancer	CCLE	NPQMRYTLSP	CBL_PTK	0.7523
p.R20W	23132-87	stomach	COSMIC	NPQMRYTLSP	CBL_PTK	0.7523
p.G24E	ACH-000835	Sarcoma	CCLE	NPQMRYTLSP	CBL_PTK	0.7199
p.G24E	GCT	soft_tissue	COSMIC	NPQMRYTLSP	CBL_PTK	0.7199
p.E18D	ACH-000997	Colon/Colorectal Cancer	CCLE	NPQMRYTLSP	CBL_PTK	0.6758
p.E18D	HCT-15	large_intestine	COSMIC	NPQMRYTLSP	CBL_PTK	0.6758
p.R15P	ACH-001061	Colon/Colorectal Cancer	CCLE	NPQMRYTLSP	CBL_PTK	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NPQMRYTLSP

Degron related mutations and impact score

Drug responses associated with HECW2 mutations

All proteins holding degron of NPQMRYTLSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2P5	E3 ubiquitin-protein ligase HECW2	CBL_PTK	16:25	NPQMRYTLSP	CBL	0.9966	More...