DegronMD

Uniprot ID: Q9P2P5

Source protein: E3 ubiquitin-protein ligase HECW2

Source gene: HECW2

Class: DEG_APCC_DBOX_1

Location: 5:13

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6457

ASA_SCORE: 91.3778

COIL: 0.359

CONS_SCORE: 0.3371

DSS_SCORE: 0.544

HELIX: 0.6139

FCONS_SCORE: 0.9776

RIG_SCORE: 0.8005

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R15Q	TCGA-AA-A00N	COAD	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	0.2778
p.R15Q	TCGA-D3-A2J8	SKCM	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	0.2778
p.R15Q	TCGA-XK-AAJ3	PRAD	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	0.2778
p.R15Q	DO228471	BRCA	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.2778
p.R15Q	DO9876	COAD	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.2778
p.R15Q	DO51408	PRAD	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.2778
p.R15Q	DO37778	SKCM	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.2778
p.R14H	TCGA-AG-3731	READ	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	0.3056
p.R14H	TCGA-CG-5721	STAD	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	0.3056
p.R14H	DO233731	GACA	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.3056
p.R14H	DO36463	READ	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.3056
p.R14H	DO38192	STAD	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.3056
p.R14C	TCGA-AX-A1CE	UCEC	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	0.3056
p.R14C	DO42280	UCEC	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.3056
p.R14C	SIDM02059	Colorectal Carcinoma	GDSC	AREHLLFVR	DEG_APCC_DBOX_1	0.3056
p.S4L	TCGA-EE-A3AH	SKCM	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	0.75
p.S4L	TCGA-FR-A729	SKCM	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	0.75
p.S4L	DO222635	MELA	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.75
p.S4L	DO37443	SKCM	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.75
p.S4L	DO48618	SKCM	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.75
p.V12A	TCGA-FF-8041	DLBC	TCGA	AREHLLFVR	DEG_APCC_DBOX_1	0.6936
p.V12A	DO222305	DLBC	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.6936
p.A2D	DO50406	ESAD	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.6944
p.E7K	DO222420	MELA	ICGC	AREHLLFVR	DEG_APCC_DBOX_1	0.591
p.G3W	ACH-000975	Lung Cancer	CCLE	AREHLLFVR	DEG_APCC_DBOX_1	0.7222
p.R15P	ACH-001061	Colon/Colorectal Cancer	CCLE	AREHLLFVR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2P5	E3 ubiquitin-protein ligase HECW2	DEG_APCC_DBOX_1	5:13	AREHLLFVR	APC,CDC20,FZR1	0.6457	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons