DegronMD

Uniprot ID: Q5T011

Source protein: KICSTOR complex protein SZT2

Source gene: SZT2

Class: DEG_SPOP_SBC_1

Location: 874:878

E3 ligase: SPOP

DEGRON score: 0.9468

ASA_SCORE: 70.78

COIL: 0.751

CONS_SCORE: 0.3024

DSS_SCORE: 0.414

HELIX: 0.0252

FCONS_SCORE: 0.8621

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F883S	TCGA-AA-3815	COAD	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1944
p.D888N	TCGA-BS-A0U7	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.0556
p.P873L	TCGA-D1-A16F	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.3056
p.L871I	TCGA-DU-6392	LGG	TCGA	PHSTS	DEG_SPOP_SBC_1	0.25
p.S884L	TCGA-EO-A22U	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1667
p.D874N	DO15623	HNSC	ICGC	PHSTS	DEG_SPOP_SBC_1	0.6932
p.V882L	DO229022	LICA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.2222
p.G885D	DO35242	PACA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1389
p.P867S	DO218884	SKCA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1389
p.P867S	DO37406	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1389
p.D887N	SIDM00193	Colorectal Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.0833
p.D887N	ACH-000991	Colon/Colorectal Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	0.0833
p.D887N	SNU-81	large_intestine	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2975:2979	PHSTS	SPOP	0.9883	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	379:383	PHSTS	SPOP	0.8054	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	874:878	PHSTS	SPOP	0.9468	More...
Q8HWS3	DNA-binding protein RFX6	DEG_SPOP_SBC_1	711:715	PHSTS	SPOP	0.9944	More...
Q8NG27	E3 ubiquitin-protein ligase Praja-1	DEG_SPOP_SBC_1	284:288	PHSTS	SPOP	0.7228	More...
Q9P2P5	E3 ubiquitin-protein ligase HECW2	DEG_SPOP_SBC_1	905:909	PHSTS	SPOP	0.9068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons