DegronMD - Q5T011(SZT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K2145N	TCGA-17-Z000	LUAD	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.25
p.V2135I	TCGA-19-1787	GBM	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.7076
p.V2135I	SIDM02013	Colorectal Carcinoma	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.7076
p.A762S	TCGA-50-5930	LUAD	TCGA	DYR	CBL_MET	759:761	Mutation rewiring degron network	0.3056
p.A762S	DO25189	LUAD	ICGC	DYR	CBL_MET	759:761	Mutation rewiring degron network	0.3056
p.R2980L	TCGA-55-6981	LUAD	TCGA	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.1944
p.R2980L	TCGA-D3-A2JK	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.1944
p.R2980L	TCGA-FS-A1ZK	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.1944
p.R2980L	TCGA-FS-A1ZS	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.1944
p.L544V	TCGA-62-8399	LUAD	TCGA	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.25
p.L544V	DO24606	LUAD	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.25
p.S539Y	TCGA-85-A4JC	LUSC	TCGA	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation altering degron motif	0.712
p.S539Y	DO45429	LUSC	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation altering degron motif	0.712
p.F883S	TCGA-AA-3815	COAD	TCGA	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.1944
p.L2124I	TCGA-AG-A002	READ	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.0556
p.L2124I	TCGA-BK-A6W3	UCEC	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.0556
p.L2124I	TCGA-EO-A3AV	UCEC	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.0556
p.L1360M	TCGA-AN-A0AK	BRCA	TCGA	PFSSS	DEG_SPOP_SBC_1	1367:1371	Mutation rewiring degron network	0.1389
p.E1357D	TCGA-AP-A0LM	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	1367:1371	Mutation rewiring degron network	0.0556
p.G2347R	TCGA-B0-4827	KIRC	TCGA	VDSSS	DEG_SPOP_SBC_1	2343:2347	Mutation altering degron motif	0.7568
p.R2127C	TCGA-BG-A18A	UCEC	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation blocking phosphorylation signal	0.5833
p.R2127C	TCGA-P5-A737	LGG	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation blocking phosphorylation signal	0.5833
p.D888N	TCGA-BS-A0U7	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.0556
p.L750F	TCGA-CG-5728	STAD	TCGA	DYR	CBL_MET	759:761	Mutation rewiring degron network	0.0833
p.L750F	DO38619	STAD	ICGC	DYR	CBL_MET	759:761	Mutation rewiring degron network	0.0833
p.P873L	TCGA-D1-A16F	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.3056
p.H2984L	TCGA-D9-A4Z3	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.0833
p.L871I	TCGA-DU-6392	LGG	TCGA	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.25
p.A1370V	TCGA-DU-6392	LGG	TCGA	PFSSS	DEG_SPOP_SBC_1	1367:1371	Mutation altering degron motif	0.6936
p.D1362N	TCGA-EA-A78R	CESC	TCGA	PFSSS	DEG_SPOP_SBC_1	1367:1371	Mutation rewiring degron network	0.1944
p.P542L	TCGA-EB-A3Y7	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.3056
p.P542L	DO37499	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.3056
p.G538C	TCGA-EE-A3AA	SKCM	TCGA	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation altering degron motif	0.6489
p.G538C	DO37571	SKCM	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation altering degron motif	0.6489
p.I1378T	TCGA-EO-A22R	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	1367:1371	Mutation rewiring degron network	0.1389
p.P536S	TCGA-EO-A22U	UCEC	TCGA	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.3056
p.P536S	DO43755	UCEC	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.3056
p.R761W	TCGA-EO-A22U	UCEC	TCGA	DYR	CBL_MET	759:761	Mutation altering degron motif	0.8634
p.S884L	TCGA-EO-A22U	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.1667
p.I751V	TCGA-FZ-5920	PAAD	TCGA	DYR	CBL_MET	759:761	Mutation rewiring degron network	0.1111
p.I751V	DO49400	PAAD	ICGC	DYR	CBL_MET	759:761	Mutation rewiring degron network	0.1111
p.A2131V	TCGA-VQ-A91D	STAD	TCGA	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.25
p.E2355K	DO6323	CESC	ICGC	VDSSS	DEG_SPOP_SBC_1	2343:2347	Mutation rewiring degron network	0.1111
p.H533R	DO222769	COCA	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.2222
p.P2345L	DO222769	COCA	ICGC	VDSSS	DEG_SPOP_SBC_1	2343:2347	Mutation altering degron motif	0.7582
p.R549H	DO234407	ESAD	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.1111
p.S758C	DO223066	ESCA	ICGC	DYR	CBL_MET	759:761	Mutation rewiring degron network	0.3056
p.D874N	DO15623	HNSC	ICGC	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation altering degron motif	0.6932
p.A528V	DO22237	LGG	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.0833
p.G766W	DO229015	LICA	ICGC	DYR	CBL_MET	759:761	Mutation rewiring degron network	0.1944
p.A2353S	DO229028	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	2343:2347	Mutation rewiring degron network	0.1667
p.V882L	DO229022	LICA	ICGC	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.2222
p.R760S	DO229026	LICA	ICGC	DYR	CBL_MET	759:761	Mutation altering degron motif	0.7427
p.G2357V	DO229037	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	2343:2347	Mutation rewiring degron network	0.0556
p.R2138L	DO24265	LUAD	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.8428
p.R2138L	DO37619	SKCM	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.8428
p.R2138L	DO37806	SKCM	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.8428
p.R2138L	DO37474	SKCM	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.8428
p.S544I	DO26728	LUSC	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.25
p.G885D	DO35242	PACA	ICGC	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.1389
p.P2345S	DO36451	READ	ICGC	VDSSS	DEG_SPOP_SBC_1	2343:2347	Mutation altering degron motif	0.6752
p.P867S	DO218884	SKCA	ICGC	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.1389
p.P867S	DO37406	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.1389
p.H2142L	DO47555	SKCM	ICGC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.7313
p.A2342V	DO47767	STAD	ICGC	VDSSS	DEG_SPOP_SBC_1	2343:2347	Mutation rewiring degron network	0.3056
p.A2353V	DO43747	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	2343:2347	Mutation rewiring degron network	0.1667
p.I536T	DO42713	UCEC	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.3056
p.G550D	DO229542	UTCA	ICGC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.0833
p.R2980W	SIDM00216	Colorectal Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.1944
p.R2980W	ACH-000989	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.1944
p.R2980W	SNU-175	large intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.1944
p.V2151M	SIDM00572	Gastric Carcinoma	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.0833
p.V2151M	ACH-000911	Gastric Cancer	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.0833
p.V2151M	NUGC-3	stomach	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.0833
p.E2130D	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.2222
p.E2130D	ACH-001669	Leukemia	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.2222
p.E2130D	ACH-002238	Leukemia	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.2222
p.E2130D	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.2222
p.D887N	SIDM00193	Colorectal Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.0833
p.D887N	ACH-000991	Colon/Colorectal Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.0833
p.D887N	SNU-81	large intestine	COSMIC	PHSTS	DEG_SPOP_SBC_1	874:878	Mutation rewiring degron network	0.0833
p.C2144Y	SIDM00660	Colorectal Carcinoma	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.2778
p.C2144Y	ACH-000985	Colon/Colorectal Cancer	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.2778
p.C2144Y	LS-411N	large intestine	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation rewiring degron network	0.2778
p.L546P	SIDM00517	Head and Neck Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	537:541	Mutation rewiring degron network	0.1944
p.R2142W	SIDM00217	Colorectal Carcinoma	GDSC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.8634
p.R2142W	ACH-000999	Colon/Colorectal Cancer	CCLE	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.8634
p.R2142W	SNU-1040	large intestine	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.8634
p.V1377I	ACH-001060	Lymphoma	CCLE	PFSSS	DEG_SPOP_SBC_1	1367:1371	Mutation rewiring degron network	0.1667
p.V2985M	ACH-002287	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.0556
p.V2985M	NCI-H630	large intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.0556
p.R2985L	NCI-H1048	lung	COSMIC	PKSTS	DEG_SPOP_SBC_1	2971:2975	Mutation rewiring degron network	0.0556
p.P2137S	NCI-H1770	lung	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.5641
p.R2338C	MFE-319	endometrium	COSMIC	VDSSS	DEG_SPOP_SBC_1	2343:2347	Mutation rewiring degron network	0.1944
p.P2137L	NCI-H1770	lung	COSMIC	PRSPLDMVS	DEG_APCC_DBOX_1	2134:2142	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SZT2

UniProt ID: Q5T011

Entrez ID: 23334

Protein name: KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SZT2 in