DegronMD

Uniprot ID: Q5T011

Source protein: KICSTOR complex protein SZT2

Source gene: SZT2

Class: DEG_SPOP_SBC_1

Location: 2971:2975

E3 ligase: SPOP

DEGRON score: 0.5397

ASA_SCORE: 79.6

COIL: 0.8306

CONS_SCORE: 0.3085

DSS_SCORE: 0.5726

HELIX: 0.0476

FCONS_SCORE: 0.9775

RIG_SCORE: 0.5923

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2980L	TCGA-55-6981	LUAD	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1944
p.R2980L	TCGA-D3-A2JK	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1944
p.R2980L	TCGA-FS-A1ZK	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1944
p.R2980L	TCGA-FS-A1ZS	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1944
p.H2984L	TCGA-D9-A4Z3	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.0833
p.R2980W	SIDM00216	Colorectal Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	0.1944
p.R2980W	ACH-000989	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.1944
p.R2980W	SNU-175	large_intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.1944
p.V2985M	ACH-002287	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.0556
p.V2985M	NCI-H630	large_intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.R2985L	NCI-H1048	lung	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons