DegronMD - Q8NDX5(PHC3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R231H	TCGA-06-5416	GBM	TCGA	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2778
p.R231H	TCGA-06-5416	GBM	TCGA	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.R231H	DO10880	GBM	ICGC	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2778
p.R231H	DO10880	GBM	ICGC	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.S695C	TCGA-66-2734	LUSC	TCGA	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.7541
p.S695C	DO26430	LUSC	ICGC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.7541
p.L187V	TCGA-90-7964	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0556
p.L187V	DO27046	LUSC	ICGC	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0556
p.S232I	TCGA-A5-A0GA	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.25
p.S232I	TCGA-A5-A0GA	UCEC	TCGA	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.S232I	DO43763	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.25
p.S232I	DO43763	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.S240R	TCGA-AN-A04D	BRCA	TCGA	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.S240R	DO2222	BRCA	ICGC	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.S240R	DO229019	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.E883G	TCGA-AX-A06F	UCEC	TCGA	SHEDSVPSA	DEG_COP1_1	869:877	Mutation rewiring degron network	0.1667
p.A202V	TCGA-B5-A11E	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.3056
p.A202V	DO41644	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.3056
p.P145H	TCGA-B5-A11Y	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7694
p.P145H	DO40889	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7694
p.T223I	TCGA-B5-A3FA	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2778
p.T223I	DO52402	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.2778
p.T11I	TCGA-BT-A20O	BLCA	TCGA	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7078
p.T11I	DO460	BLCA	ICGC	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7078
p.I700V	TCGA-CR-6492	HNSC	TCGA	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.7076
p.I700V	DO14170	HNSC	ICGC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.7076
p.G244C	TCGA-D3-A3CB	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1667
p.G244C	DO47386	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1667
p.S695I	TCGA-DF-A2KU	UCEC	TCGA	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.7341
p.S695I	DO223286	UCEC	ICGC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.7341
p.P196L	TCGA-E6-A1LZ	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.3056
p.P196L	DO41398	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.3056
p.L865F	TCGA-EE-A2MD	SKCM	TCGA	SHEDSVPSA	DEG_COP1_1	869:877	Mutation rewiring degron network	0.2222
p.P19L	TCGA-EK-A2PI	CESC	TCGA	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1111
p.P19L	TCGA-EK-A2PI	CESC	TCGA	VSTTT	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.P19L	DO6338	CESC	ICGC	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1111
p.P19L	DO6338	CESC	ICGC	VSTTT	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.25
p.L141F	TCGA-ER-A19M	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.L141F	DO37798	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.S217F	TCGA-FW-A3R5	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1111
p.S217F	DO37406	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.1111
p.H9Y	TCGA-GN-A266	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7229
p.H9Y	DO37432	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.7229
p.S874C	TCGA-LN-A49M	ESCA	TCGA	SHEDSVPSA	DEG_COP1_1	869:877	Mutation altering degron motif	0.7541
p.N143I	DO7810	COAD	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.3056
p.N143I	DO47833	STAD	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.3056
p.L142I	DO20762	KIRP	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.2778
p.Q706K	DO228974	LICA	ICGC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation rewiring degron network	0.1667
p.R153S	DO228974	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1944
p.T15N	DO228978	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7055
p.P705A	DO228985	LICA	ICGC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation rewiring degron network	0.1944
p.L192M	DO228986	LICA	ICGC	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1944
p.E887K	DO229018	LICA	ICGC	SHEDSVPSA	DEG_COP1_1	869:877	Mutation rewiring degron network	0.0556
p.E887K	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	SHEDSVPSA	DEG_COP1_1	869:877	Mutation rewiring degron network	0.0556
p.A859E	DO229019	LICA	ICGC	SHEDSVPSA	DEG_COP1_1	869:877	Mutation rewiring degron network	0.0556
p.T137K	DO229038	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1389
p.P17Q	DO229006	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1667
p.P17Q	DO229006	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.3056
p.A2E	DO229009	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.A2E	DO229009	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.0556
p.T229K	DO229008	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7306
p.M13V	DO45259	LIRI	ICGC	VSTTT	DEG_SPOP_SBC_1	12:16	Mutation altering degron motif	0.7208
p.S239C	DO230530	LUSC	ICGC	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.S239C	DO230530	LUSC	ICGC	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.F146S	DO51474	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7982
p.F146S	GP5d	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7982
p.S211L	DO232761	PBCA	ICGC	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0556
p.F145S	DO38123	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7982
p.N143H	DO42312	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.3056
p.N143H	DO41331	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.3056
p.N143H	HCC2998	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.3056
p.E871G	DO41752	UCEC	ICGC	SHEDSVPSA	DEG_COP1_1	869:877	Mutation altering degron motif	0.7199
p.V706I	DO41847	UCEC	ICGC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation rewiring degron network	0.1667
p.F151L	DO41361	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.S695G	SIDM00993	Plasma Cell Myeloma	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.S695G	SIDM00373	Endometrial Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.S695G	SIDM00614	Hepatocellular Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.S695G	SIDM01242	Melanoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.S695G	SIDM00869	Non-Cancerous	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.S695G	SIDM00383	Gastric Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.S695G	SIDM00239	Kidney Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.S695G	SIDM00045	Gastric Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.S695G	SIDM01526	Mesothelioma	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.S695G	SIDM01464	Pancreatic Carcinoma	GDSC	PPQAIVKPQ	DEG_SIAH_1	692:700	Mutation altering degron motif	0.6993
p.R188Q	SIDM00683	Prostate Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.R188Q	ACH-000977	lymph node	CCLE	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.R188Q	ACH-001369	Ovarian Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.R188Q	LNCaP-Clone-FGC	prostate	COSMIC	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.S154C	SIDM00928	Breast Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1667
p.S154C	CAL-85-1	breast	COSMIC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1667
p.G20R	SIDM00177	Melanoma	GDSC	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.0833
p.G20R	SIDM00177	Melanoma	GDSC	VSTTT	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.2222
p.G20R	ACH-002338	Skin Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.0833
p.G20R	ACH-002338	Skin Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.2222
p.G20R	ACH-002510	Skin Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.0833
p.G20R	ACH-002510	Skin Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	12:16	Mutation rewiring degron network	0.2222
p.R243Q	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1944
p.Q198E	JHH-1	liver	COSMIC	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.6744
p.Q200H	LAN-6	autonomic ganglia	COSMIC	VVSSS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7582
p.F142S	GP5d	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.2778
p.A877V	CW-2	large intestine	COSMIC	SHEDSVPSA	DEG_COP1_1	869:877	Mutation altering degron motif	0.5825
p.Q239E	JHH-1	liver	COSMIC	VLSSS	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.Q239E	JHH-1	liver	COSMIC	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.S142C	CAL-85-1	breast	COSMIC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.2778
p.N143K	OVK-18	ovary	COSMIC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.3056
p.N139K	OVK-18	ovary	COSMIC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1944
p.Q241H	LAN-6	autonomic ganglia	COSMIC	PKSTS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.N139H	HCC2998	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHC3

UniProt ID: Q8NDX5

Entrez ID: 80012

Protein name: Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHC3 in