DegronMD

Uniprot ID: Q8NDX5

Source protein: Polyhomeotic-like protein 3

Source gene: PHC3

Class: DEG_SPOP_SBC_1

Location: 234:238

E3 ligase: SPOP

DEGRON score: 0.6925

ASA_SCORE: 95.28

COIL: 0.9356

CONS_SCORE: 0.4427

DSS_SCORE: 0.6585

HELIX: 0.0374

FCONS_SCORE: 0.9951

RIG_SCORE: 0.5839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R231H	TCGA-06-5416	GBM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.25
p.R231H	DO10880	GBM	ICGC	PKSTS	DEG_SPOP_SBC_1	0.25
p.S232I	TCGA-A5-A0GA	UCEC	TCGA	PKSTS	DEG_SPOP_SBC_1	0.2778
p.S232I	DO43763	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2778
p.S240R	TCGA-AN-A04D	BRCA	TCGA	PKSTS	DEG_SPOP_SBC_1	0.2778
p.S240R	DO2222	BRCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2778
p.S240R	DO229019	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2778
p.G244C	TCGA-D3-A3CB	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1667
p.G244C	DO47386	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1667
p.S239C	DO230530	LUSC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.R243Q	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.1944
p.Q239E	JHH-1	liver	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.Q241H	LAN-6	autonomic_ganglia	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons