DELE1
UniProt ID: Q14154
Entrez ID: 9812
Protein name: DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1)]
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: [DAP3-binding cell death enhancer 1]: Key activator of the integrated stress response (ISR) following mitochondrial stress (PubMed:32132706, PubMed:32132707). In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DE...
FUNCTION: [DAP3-binding cell death enhancer 1]: Key activator of the integrated stress response (ISR) following mitochondrial stress (PubMed:32132706, PubMed:32132707). In response to mitochondrial stress, cleaved by the protease OMA1, generating the DAP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR (PubMed:32132706, PubMed:32132707). Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). {ECO:0000269|PubMed:20563667, ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707}.; FUNCTION: [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707). It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707). {ECO:0000269|PubMed:32132706, ECO:0000269|PubMed:32132707}.
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GO - Biological processes (BP):
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]...
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; HRI-mediated signaling [GO:0140468]; integrated stress response signaling [GO:0140467]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]
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GO - Molecular function (MF):
protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]...
protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]
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GO - Cellular component (CC):
cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]...
cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]
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DELE1
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*NOTE: the Kaplan plots were collected from OncoLnc