DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTPKST
Uniprot ID:
Q14154
Source protein:
DAP3-binding cell death enhancer 1
Source gene:
DELE1
Class:
DEG_SCF_FBW7_1
Location:
23:28
E3 ligase:
FBXW7
DEGRON score:
0.9903
ASA_SCORE:
77.1
COIL:
0.907
CONS_SCORE:
0.4021
DSS_SCORE:
0.6486
HELIX:
0.0093
FCONS_SCORE:
1.0421
RIG_SCORE:
0.671
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R14C
SIDM00220
Ovarian Carcinoma
GDSC
VTPKST
DEG_SCF_FBW7_1
0.0833
p.R14C
OC-314
ovary
COSMIC
VTPKST
DEG_SCF_FBW7_1
0.0833
Drug responses associated with DELE1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPKST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14154
DAP3-binding cell death enhancer 1
DEG_SCF_FBW7_1
23:28
VTPKST
FBXW7
0.9903
More...