DegronMD - O43497(CACNA1G)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1057S	TCGA-ER-A19F	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.2778
p.G1057S	DO222837	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.2778
p.G1057S	DO37679	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.2778
p.G544W	TCGA-G7-6795	KIRP	TCGA	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.3056
p.G544W	DO20851	KIRP	ICGC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.3056
p.A550T	TCGA-WS-AB45	COAD	TCGA	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1389
p.A550T	DO51734	COAD	ICGC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1389
p.A545P	DO5808	BRCA	ICGC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.2778
p.A545P	SIDM02021	Esophageal Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.2778
p.A526S	DO229022	LICA	ICGC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.0556
p.G528W	DO229026	LICA	ICGC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1111
p.G1059N	DO220851	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.2222
p.G1059S	DO220851	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.2222
p.G1059D	DO220851	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.2222
p.P1047S	DO220886	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.2222
p.S543F	DO222843	MELA	ICGC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation altering degron motif	0.7982
p.G549D	SIDM02039	Colorectal Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1667
p.G549A	SIDM00866	Breast Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1667
p.G549A	SIDM00868	Non-Cancerous	GDSC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1667
p.R531W	SIDM00845	Burkitt's Lymphoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1944
p.R530H	SIDM01039	Other Solid Cancers	GDSC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1667
p.R530H	SIDM00875	Breast Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1667
p.R530H	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	536:543	Mutation rewiring degron network	0.1667
p.A1061V	ACH-001536	Bile Duct Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.1667
p.T1056A	ACH-002305	Head and Neck Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.3056
p.T1056A	SKN-3	upper aerodigestive tract	COSMIC	PKSTS	DEG_SPOP_SBC_1	1051:1055	Mutation rewiring degron network	0.3056

Kaplan plot for CACNA1G in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNA1G

UniProt ID: O43497

Entrez ID: 8913

Protein name: Voltage-dependent T-type calcium channel subunit alpha-1G (Cav3.1c) (NBR13) (Voltage-gated calcium channel subunit alpha Cav3.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CACNA1G in