DegronMD

Uniprot ID: O43497

Source protein: Voltage-dependent T-type calcium channel subunit alpha-1G

Source gene: CACNA1G

Class: DEG_SCF_FBW7_1

Location: 536:543

E3 ligase: FBXW7

DEGRON score: 0.9607

ASA_SCORE: 77.2

COIL: 0.9245

CONS_SCORE: 0.27

DSS_SCORE: 0.6807

HELIX: 0.0481

FCONS_SCORE: 1.0166

RIG_SCORE: 0.578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G544W	TCGA-G7-6795	KIRP	TCGA	PPSTPALS	DEG_SCF_FBW7_1	0.3056
p.G544W	DO20851	KIRP	ICGC	PPSTPALS	DEG_SCF_FBW7_1	0.3056
p.A550T	TCGA-WS-AB45	COAD	TCGA	PPSTPALS	DEG_SCF_FBW7_1	0.1389
p.A550T	DO51734	COAD	ICGC	PPSTPALS	DEG_SCF_FBW7_1	0.1389
p.A545P	DO5808	BRCA	ICGC	PPSTPALS	DEG_SCF_FBW7_1	0.2778
p.A545P	SIDM02021	Esophageal Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	0.2778
p.A526S	DO229022	LICA	ICGC	PPSTPALS	DEG_SCF_FBW7_1	0.0556
p.G528W	DO229026	LICA	ICGC	PPSTPALS	DEG_SCF_FBW7_1	0.1111
p.S543F	DO222843	MELA	ICGC	PPSTPALS	DEG_SCF_FBW7_1	0.7982
p.G549D	SIDM02039	Colorectal Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	0.1667
p.G549A	SIDM00866	Breast Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	0.1667
p.G549A	SIDM00868	Non-Cancerous	GDSC	PPSTPALS	DEG_SCF_FBW7_1	0.1667
p.R531W	SIDM00845	Burkitt's Lymphoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	0.1944
p.R530H	SIDM01039	Other Solid Cancers	GDSC	PPSTPALS	DEG_SCF_FBW7_1	0.1667
p.R530H	SIDM00875	Breast Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	0.1667
p.R530H	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PPSTPALS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SCF_FBW7_1	536:543	PPSTPALS	FBXW7	0.9607	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons