DegronMD

Uniprot ID: O43497

Source protein: Voltage-dependent T-type calcium channel subunit alpha-1G

Source gene: CACNA1G

Class: DEG_SPOP_SBC_1

Location: 1051:1055

E3 ligase: SPOP

DEGRON score: 0.9183

ASA_SCORE: 74.64

COIL: 0.7828

CONS_SCORE: 0.3384

DSS_SCORE: 0.5873

HELIX: 0.0616

FCONS_SCORE: 1.012

RIG_SCORE: 0.662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1057S	TCGA-ER-A19F	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.2778
p.G1057S	DO222837	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2778
p.G1057S	DO37679	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2778
p.G1059N	DO220851	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.G1059S	DO220851	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.G1059D	DO220851	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.P1047S	DO220886	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.A1061V	ACH-001536	Bile Duct Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.1667
p.T1056A	ACH-002305	Head and Neck Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.3056
p.T1056A	SKN-3	upper_aerodigestive_tract	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons