DegronMD

Uniprot ID: O75132

Source protein: Zinc finger BED domain-containing protein 4

Source gene: ZBED4

Class: DEG_SPOP_SBC_1

Location: 278:282

E3 ligase: SPOP

DEGRON score: 0.8251

ASA_SCORE: 101.48

COIL: 0.9308

CONS_SCORE: 0.4043

DSS_SCORE: 0.4917

HELIX: 0.0402

FCONS_SCORE: 1.1162

RIG_SCORE: 0.6318

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G283R	TCGA-18-3409	LUSC	TCGA	PKSTS	DEG_SPOP_SBC_1	0.3056
p.G283R	DO26444	LUSC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.K273N	TCGA-85-6561	LUSC	TCGA	PKSTS	DEG_SPOP_SBC_1	0.6389
p.K273N	DO26518	LUSC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.6389
p.K273E	TCGA-UY-A8OB	BLCA	TCGA	PKSTS	DEG_SPOP_SBC_1	0.6389
p.K273E	DO219037	BLCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.6389
p.R286K	DO218874	SKCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.R287K	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	0.1944
p.R287K	SIDM01680	Non-Cancerous	GDSC	PKSTS	DEG_SPOP_SBC_1	0.1944
p.R287K	ACH-000589	Lung Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.1944
p.R287K	ACH-002364	Non-Cancerous	CCLE	PKSTS	DEG_SPOP_SBC_1	0.1944
p.K292Q	ACH-000127	Bladder Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons