DegronMD - O75132(ZBED4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G283R	TCGA-18-3409	LUSC	TCGA	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.3056
p.G283R	DO26444	LUSC	ICGC	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.3056
p.K273N	TCGA-85-6561	LUSC	TCGA	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation blocking ubiquitination signal	0.6389
p.K273N	DO26518	LUSC	ICGC	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation blocking ubiquitination signal	0.6389
p.A531E	TCGA-90-7769	LUSC	TCGA	AESSS	DEG_SPOP_SBC_1	531:535	Mutation altering degron motif	0.7701
p.A531E	DO26822	LUSC	ICGC	AESSS	DEG_SPOP_SBC_1	531:535	Mutation altering degron motif	0.7701
p.D418N	TCGA-A5-A2K5	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.3056
p.D418N	DO41379	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.3056
p.P349L	TCGA-AA-3845	COAD	TCGA	PPLY	ITCH	349:352	Mutation altering degron motif	0.7582
p.P349L	DO10020	COAD	ICGC	PPLY	ITCH	349:352	Mutation altering degron motif	0.7582
p.S416F	TCGA-D3-A8GQ	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7982
p.S416F	DO51246	SKCM	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7982
p.F414L	TCGA-DU-6392	LGG	TCGA	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.587
p.F414L	DO22237	LGG	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.587
p.A412V	TCGA-EY-A1GU	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.3056
p.A412V	DO41518	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.3056
p.V544A	TCGA-G4-6586	COAD	TCGA	AESSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0833
p.V544A	DO9698	COAD	ICGC	AESSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0833
p.P403L	TCGA-KL-8340	KICH	TCGA	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.P403L	DO220348	KICH	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.K273E	TCGA-UY-A8OB	BLCA	TCGA	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation blocking ubiquitination signal	0.6389
p.K273E	DO219037	BLCA	ICGC	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation blocking ubiquitination signal	0.6389
p.S427F	TCGA-W3-AA1V	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.S427F	DO51276	SKCM	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0556
p.T346M	DO222737	COCA	ICGC	PPLY	ITCH	349:352	Mutation rewiring degron network	0.25
p.I420V	DO229010	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.25
p.I420V	DO229013	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.25
p.I420V	DO229016	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.25
p.I420V	DO229003	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.25
p.I420V	DO229005	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.25
p.I420V	DO234285	ESAD	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.25
p.V545F	DO229018	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0556
p.D419E	DO220891	MELA	ICGC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.2778
p.P524L	DO222494	MELA	ICGC	AESSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.1389
p.R286K	DO218874	SKCA	ICGC	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.A521T	SIDM00553	Acute Myeloid Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0556
p.A521T	ACH-002262	Leukemia	CCLE	AESSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0556
p.A521T	KY821	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	531:535	Mutation rewiring degron network	0.0556
p.P349R	SIDM00846	Cervical Carcinoma	GDSC	PPLY	ITCH	349:352	Mutation altering degron motif	0.7512
p.V411M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.2778
p.V411M	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.2778
p.R287K	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1944
p.R287K	SIDM01680	Non-Cancerous	GDSC	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1944
p.R287K	ACH-000589	Lung Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1944
p.R287K	ACH-002364	Non-Cancerous	CCLE	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1944
p.P360L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	349:352	Mutation rewiring degron network	0.1111
p.P360L	ACH-000904	Lung Cancer	CCLE	PPLY	ITCH	349:352	Mutation rewiring degron network	0.1111
p.P360L	ACH-001362	Lung Cancer	CCLE	PPLY	ITCH	349:352	Mutation rewiring degron network	0.1111
p.P360L	NCI-H1770	lung	COSMIC	PPLY	ITCH	349:352	Mutation rewiring degron network	0.1111
p.K292Q	ACH-000127	Bladder Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	278:282	Mutation substituting flanking lysine	0.1667
p.G347S	ACH-000973	Bladder Cancer	CCLE	PPLY	ITCH	349:352	Mutation rewiring degron network	0.2778

Kaplan plot for ZBED4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBED4

UniProt ID: O75132

Entrez ID: 9889

Protein name: Zinc finger BED domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBED4 in