DegronMD

Uniprot ID: O75132

Source protein: Zinc finger BED domain-containing protein 4

Source gene: ZBED4

Class: DEG_SPOP_SBC_1

Location: 413:417

E3 ligase: SPOP

DEGRON score: 0.5892

ASA_SCORE: 67.64

COIL: 0.7182

CONS_SCORE: 0.2993

DSS_SCORE: 0.5951

HELIX: 0.1986

FCONS_SCORE: 0.9361

RIG_SCORE: 0.6799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D418N	TCGA-A5-A2K5	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.3056
p.D418N	DO41379	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.S416F	TCGA-D3-A8GQ	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	0.7982
p.S416F	DO51246	SKCM	ICGC	AFSSS	DEG_SPOP_SBC_1	0.7982
p.F414L	TCGA-DU-6392	LGG	TCGA	AFSSS	DEG_SPOP_SBC_1	0.587
p.F414L	DO22237	LGG	ICGC	AFSSS	DEG_SPOP_SBC_1	0.587
p.A412V	TCGA-EY-A1GU	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.3056
p.A412V	DO41518	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.P403L	TCGA-KL-8340	KICH	TCGA	AFSSS	DEG_SPOP_SBC_1	0.0556
p.P403L	DO220348	KICH	ICGC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S427F	TCGA-W3-AA1V	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S427F	DO51276	SKCM	ICGC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.I420V	DO229010	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.25
p.I420V	DO229013	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.25
p.I420V	DO229016	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.25
p.I420V	DO229003	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.25
p.I420V	DO229005	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.25
p.I420V	DO234285	ESAD	ICGC	AFSSS	DEG_SPOP_SBC_1	0.25
p.D419E	DO220891	MELA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.V411M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.V411M	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons