DegronMD

Uniprot ID: Q8N103

Source protein: T-cell activation Rho GTPase-activating protein

Source gene: TAGAP

Class: DEG_SPOP_SBC_1

Location: 459:463

E3 ligase: SPOP

DEGRON score: 0.9042

ASA_SCORE: 77.62

COIL: 0.7296

CONS_SCORE: 0.4991

DSS_SCORE: 0.2662

HELIX: 0.238

FCONS_SCORE: 1.0813

RIG_SCORE: 0.7036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D470E	TCGA-17-Z027	LUAD	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1389
p.F460V	TCGA-AA-A00N	COAD	TCGA	AFSSS	DEG_SPOP_SBC_1	0.5957
p.F460L	TCGA-AG-3731	READ	TCGA	AFSSS	DEG_SPOP_SBC_1	0.587
p.F460S	TCGA-CM-6161	COAD	TCGA	AFSSS	DEG_SPOP_SBC_1	0.6871
p.S469F	TCGA-FS-A1ZA	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1667
p.A467T	TCGA-VR-AA7D	ESCA	TCGA	AFSSS	DEG_SPOP_SBC_1	0.2222
p.P458H	DO230334	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.H464R	DO21571	LAML	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.H464Q	DO229041	LICA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.A452V	DO219153	LUSC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1389
p.P460L	DO220886	MELA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.7582
p.M449I	DO220040	SARC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.R453W	SIDM00602	Gastric Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.1667
p.R453W	ACH-000919	Gastric Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.1667
p.R453W	IM-95	stomach	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1667
p.S464T	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.S464T	ACH-000893	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.3056
p.S464T	NCI-H1651	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.S449L	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S449L	ACH-000869	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S449L	NCI-H1568	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.P461S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.6752
p.R453L	DB	haematopoietic_and_lymphoid_tissue	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons