DegronMD - O94823(ATP10B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K542N	TCGA-06-1805	GBM	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation altering degron motif	0.5806
p.K542N	DO11567	GBM	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation altering degron motif	0.5806
p.R527C	TCGA-AJ-A3EL	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.1111
p.R527C	TCGA-AX-A0J1	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.1111
p.R527C	DO41542	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.1111
p.R527C	DO41199	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.1111
p.R527C	SIDM01588	Endometrial Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.1111
p.R527C	ACH-000993	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.1111
p.K553E	TCGA-AP-A0LM	UCEC	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation substituting flanking lysine	0.3056
p.K553E	DO43306	UCEC	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation substituting flanking lysine	0.3056
p.S538R	TCGA-AX-A1CE	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation altering degron motif	0.7427
p.S538R	DO42280	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation altering degron motif	0.7427
p.S538R	ACH-001143	Lymphoma	CCLE	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation altering degron motif	0.7427
p.A994V	TCGA-AX-A2HD	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1111
p.A994V	DO42608	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1111
p.D547H	TCGA-BB-4227	HNSC	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation altering degron motif	0.6577
p.D547H	DO15855	HNSC	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation altering degron motif	0.6577
p.S530P	TCGA-C8-A12X	BRCA	TCGA	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.1944
p.S530P	DO3751	BRCA	ICGC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.1944
p.R977C	TCGA-D1-A17Q	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.2778
p.R977C	TCGA-FI-A2D0	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.2778
p.R977C	DO41903	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.2778
p.R977C	DO43891	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.2778
p.V534A	TCGA-DD-AACX	LIHC	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.1389
p.V534A	TCGA-DD-AACX	LIHC	TCGA	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.3056
p.V534A	DO52215	LIHC	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.1389
p.V534A	DO52215	LIHC	ICGC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.3056
p.G975E	TCGA-E9-A1NE	BRCA	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.2222
p.G975E	DO1436	BRCA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.2222
p.P969Q	TCGA-EE-A181	SKCM	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.0556
p.P969Q	DO37444	SKCM	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.0556
p.V991I	TCGA-EE-A3AA	SKCM	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1944
p.V991I	DO222632	MELA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1944
p.V991I	DO37571	SKCM	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1944
p.A989D	TCGA-EO-A3AV	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.25
p.A989D	DO52412	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.25
p.E541K	TCGA-ER-A194	SKCM	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation altering degron motif	0.591
p.E541K	DO47646	SKCM	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation altering degron motif	0.591
p.A994P	TCGA-FD-A3B4	BLCA	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1111
p.A994P	DO862	BLCA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1111
p.K972R	TCGA-FI-A2F4	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation substituting flanking lysine	0.25
p.K972R	DO43434	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation substituting flanking lysine	0.25
p.S984Y	TCGA-FV-A3R2	LIHC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation altering degron motif	0.6009
p.S984Y	DO44994	LIHC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation altering degron motif	0.6009
p.P969S	TCGA-HZ-A49H	PAAD	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.0556
p.P969S	DO32799	PAAD	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.0556
p.E993D	TCGA-L5-A8NE	ESCA	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1389
p.P979H	TCGA-O2-A52Q	LUSC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation altering degron motif	0.7694
p.P979H	DO219219	LUSC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation altering degron motif	0.7694
p.A558S	TCGA-OR-A5K8	ACC	TCGA	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.0556
p.A535V	TCGA-WS-AB45	COAD	TCGA	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation altering degron motif	0.5825
p.A535V	DO51734	COAD	ICGC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation altering degron motif	0.5825
p.D547E	DO233171	GACA	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation altering degron motif	0.5647
p.K548N	DO233171	GACA	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation altering degron motif	0.6918
p.T982K	DO229025	LICA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation altering degron motif	0.7306
p.P969T	DO229036	LICA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.0556
p.A558V	DO50721	ORCA	ICGC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.0556
p.A558V	KYSE-220	oesophagus	COSMIC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.0556
p.D970H	SIDM00693	Bladder Carcinoma	GDSC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.0833
p.D970H	ACH-000396	Bladder Cancer	CCLE	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.0833
p.D970H	J82	urinary tract	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.0833
p.T986A	SIDM00683	Prostate Carcinoma	GDSC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation altering degron motif	0.7139
p.T986A	ACH-000977	lymph node	CCLE	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation altering degron motif	0.7139
p.T986A	LNCaP-Clone-FGC	prostate	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation altering degron motif	0.7139
p.I540T	SIDM00674	Non-Cancerous	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.3056
p.I540T	SIDM00674	Non-Cancerous	GDSC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.3056
p.I540T	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.3056
p.I540T	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.3056
p.I540T	SIDM00844	Burkitt's Lymphoma	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.3056
p.I540T	SIDM00844	Burkitt's Lymphoma	GDSC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.3056
p.I540T	SIDM01664	Prostate Carcinoma	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.3056
p.I540T	SIDM01664	Prostate Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.3056
p.I540T	SIDM01525	Acute Myeloid Leukemia	GDSC	EKDVTPDK	DEG_SCF_SKP2-CKS1_1	541:548	Mutation rewiring degron network	0.3056
p.I540T	SIDM01525	Acute Myeloid Leukemia	GDSC	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation rewiring degron network	0.3056
p.R971H	SIDM01140	Ovarian Carcinoma	GDSC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1111
p.S538I	ACH-000790	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	535:539	Mutation altering degron motif	0.7341
p.E984G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation altering degron motif	0.7199
p.R995L	HCT-15	large intestine	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.0833
p.D971Y	SNU-81	large intestine	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	979:986	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP10B

UniProt ID: O94823

Entrez ID: 23120

Protein name: Phospholipid-transporting ATPase VB (EC 7.6.2.1) (ATPase class V type 10B) (P4-ATPase flippase complex alpha subunit ATP10B)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ATP10B in