DegronMD

Uniprot ID: O94823

Source protein: Phospholipid-transporting ATPase VB

Source gene: ATP10B

Class: DEG_SCF_FBW7_1

Location: 979:986

E3 ligase: FBXW7

DEGRON score: 0.882

ASA_SCORE: 84.425

COIL: 0.9104

CONS_SCORE: 0.162

DSS_SCORE: 0.2923

HELIX: 0.0444

FCONS_SCORE: 0.4614

RIG_SCORE: 0.7047

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A994V	TCGA-AX-A2HD	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.1111
p.A994V	DO42608	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.1111
p.R977C	TCGA-D1-A17Q	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.2778
p.R977C	TCGA-FI-A2D0	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.2778
p.R977C	DO41903	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.2778
p.R977C	DO43891	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.2778
p.G975E	TCGA-E9-A1NE	BRCA	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.2222
p.G975E	DO1436	BRCA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.2222
p.P969Q	TCGA-EE-A181	SKCM	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.0556
p.P969Q	DO37444	SKCM	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.0556
p.V991I	TCGA-EE-A3AA	SKCM	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.1944
p.V991I	DO222632	MELA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.1944
p.V991I	DO37571	SKCM	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.1944
p.A989D	TCGA-EO-A3AV	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.25
p.A989D	DO52412	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.25
p.A994P	TCGA-FD-A3B4	BLCA	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.1111
p.A994P	DO862	BLCA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.1111
p.K972R	TCGA-FI-A2F4	UCEC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.25
p.K972R	DO43434	UCEC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.25
p.S984Y	TCGA-FV-A3R2	LIHC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.6009
p.S984Y	DO44994	LIHC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.6009
p.P969S	TCGA-HZ-A49H	PAAD	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.0556
p.P969S	DO32799	PAAD	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.0556
p.E993D	TCGA-L5-A8NE	ESCA	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.1389
p.P979H	TCGA-O2-A52Q	LUSC	TCGA	PSKTPSIT	DEG_SCF_FBW7_1	0.7694
p.P979H	DO219219	LUSC	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.7694
p.T982K	DO229025	LICA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.7306
p.P969T	DO229036	LICA	ICGC	PSKTPSIT	DEG_SCF_FBW7_1	0.0556
p.D970H	SIDM00693	Bladder Carcinoma	GDSC	PSKTPSIT	DEG_SCF_FBW7_1	0.0833
p.D970H	ACH-000396	Bladder Cancer	CCLE	PSKTPSIT	DEG_SCF_FBW7_1	0.0833
p.D970H	J82	urinary_tract	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	0.0833
p.T986A	SIDM00683	Prostate Carcinoma	GDSC	PSKTPSIT	DEG_SCF_FBW7_1	0.7139
p.T986A	ACH-000977	lymph_node	CCLE	PSKTPSIT	DEG_SCF_FBW7_1	0.7139
p.T986A	LNCaP-Clone-FGC	prostate	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	0.7139
p.R971H	SIDM01140	Ovarian Carcinoma	GDSC	PSKTPSIT	DEG_SCF_FBW7_1	0.1111
p.E984G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	0.7199
p.R995L	HCT-15	large_intestine	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	0.0833
p.D971Y	SNU-81	large_intestine	COSMIC	PSKTPSIT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSKTPSIT

Degron related mutations and impact score

Drug responses associated with ATP10B mutations

All proteins holding degron of PSKTPSIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94823	Phospholipid-transporting ATPase VB	DEG_SCF_FBW7_1	979:986	PSKTPSIT	FBXW7	0.882	More...